Sirenas LLC

Maze Therapeutics, Inc.

Alexander Wayne Schammel

David John Morgans, Jr

Birong Zhang

Steven Bruce Cohen

Ippei Usui

Jacob Neal Beverage

Bryan Junn Lee

Patrick Sang Tae Lee

Christopher Joseph Sinz

Maarten Hoek

Chris Ziebenhaus

Todd Jonathan August Ewing

Victoria Anne Assimon

Elizabeth Paige Stout

Adam Neil Reid

Sarah M Bronner

Venkat Rami Reddy Macherla

Venkata Rami Reddy Macherla

Eduardo Esquenazi

Oliver Booth Vining

Provided herein are compounds of formula (II):

APOL1 inhibitors and methods of use

Provided herein are compounds of formula (II): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, p, R, R, R, L, L, L, R, X, X, X, and Xare as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.

Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat diseases such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.

Anti-cancer compounds and conjugates thereof

Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.

Cyclic peptide analogs and conjugates thereof

Growing community of inventors

San Diego, CA, United States of America

Alexander Wayne Schammel