Mount Sinai School of Medicine

Institut De Cardiologie De Montreal

Affina Biotechnologies, Inc.

Alexander Vinitsky

Steve Poirier

Gaétan Mayer

Marian Orlowski

Christopher Cardozo

Alan Berezov

The present invention relates to compounds of Table 1, which are encompassed by Formula I and/or Formula II, Ill, IV, V, or VI, and pharmaceutically acceptable salts, solvates or compositions thereof. Compounds of Table 1 are PCSK9 interacting small molecules that modulate PCSK9 activity and significantly increase low density lipoprotein receptor expression and activity, lower total circulating cholesterol and are useful for treating and delaying the onset of diseases that are associated with elevated cholesterol.

Methods of treating elevated plasma cholesterol

The present invention provides novel peptidylaldehyde inhibitors of proteolysis mediated by the multicatalytic proteinase complex (MPC) or proteasome. The inhibitors have the general formula

Substrate-related peptidyl-aldehyde inhibitors of the proteolytic

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New York, NY, United States of America

Alexander Vinitsky