Other

Billings Pharmaceuticals, Inc.

Alexander V Tatarintsev

John B Davidson

Ali S Turgiev

James K Hildreth

The invention provides enantiomers of ajoene and derivatives of Z(&#x2212;)-ajoene. The derivative of Z(&#x2212;)-ajoene are useful for modulating integrin-mediated functions, for treating disorders, diseases or conditions in which integrins play a role, and for treating tissues to improve their condition for a subsequent use, such as transplantation.

Chiral integrin modulators and methods of use thereof

The invention provides enantiomers of ajoene and derivtives of Z(&#x2212;)-ajoene. The derivative of Z(&#x2212;)-ajoene are useful for modulating integrin-mediated functions, for treating disorders, diseases or conditions in which integrins play a role, and for treating tissues to improve their condition for a subsequent use, such as transplantation.

The invention provides methods of treating inflammatory diseases and conditions by administering an effective amount of an integrin modulating agent, as further defined and specified herein, to an animal suffering from one of the diseases or conditions. The preferred integrin modulating agents are ajoene and disintegrins, variants and analogs of disintegrins.

Methods of using integrin modulators for treatment of inflammation

The present invention relates to the use of ajoene for inhibiting integrin-mediated cell-cell fusion. Specific types of cell-cell fusion are giant multinucleated cell formation, syneytia formation, and osteoclast formation.

Methods of using Ajoene for inhibiting integrin-mediated cell-cell fusion

Disclosed herein is the use of ajoene for the treatment of shock.

Methods of using Ajoene for treatment of shock

The progression of infection and other pathologies produced by a viral infection may be inhibited by administering an effective dosage of Ajoene. Additionally, Ajoene has anti-tumor, anti-shock, and antiinflammation effects. In general, Ajoene may be used to treat any integrin-mediated disease or condition.

Methods of using ajoene

The present invention relates to the use of Ajoene to treat integrin-mediated tumors and metastasis.

Methods of using ajoene for the treatment of tumors

The progression of infection and other pathologies produced by a viral infection may be inhibited by administering an effective dosage of Ajoene. Additionally, Ajoene has anti-tumor, anti-shock, and anti-inflammation effects. In general, Ajoene may be used to treat any integrin-mediated disease or condition.

Contraceptive method using ajoene

This invention relates to a method of inhibiting an immune response by administering an effective dosage of Ajoene.

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Moscow, Russia

Alexander V Tatarintsev