Life Technologies Corporation

Caliper Life Sciences, Inc.

Compensate.com LLC

Alexander V Dukhovny

Joshua Mead

John Dixon

Albert L Carrillo

Ian Walton

Robert L Cobene

Achim Karger

David M Liu

Peng Li

Joseph A Lazur

Dan Kline

Adam Sannicandro

Kirk M Hirano

Colin B Kennedy

Josh Molho

Bradley W Rice

Daniel G Stearns

Tobias Daniel Wheeler

Michael Simon

Gary Lim

Alexander Khorlin

I-Jane Chen

Joshua I Molho

Danh C Tran

David Meredith

David Beck

David Ellis

Bin Cao

Kirk Hirano

David Liu

Robert Cobene

In one aspect, a biological sequencing device comprising a cartridge configured to be removed from the instrument is disclosed. In various embodiments the cartridge can include one or more capillaries suitable for capillary electrophoresis, a reservoir and a pump. In various embodiments the reservoir can contain a separation matrix. In various embodiments the pump can load a capillary with separation matrix. In another aspect the biological sequencing device can include one or more capillaries and an integrated valve assembly. In various embodiments the integrated valve assembly can provide a polymer to the one or more capillaries.

Apparatuses, systems and methods for sequencing using capillary electrophoresis

Capillary electrophoresis cartridge

The present disclosure relates, in some embodiments, to an apparatus for conducting a capillary electrophoresis assay. The apparatus can comprise a capillary array comprising an anode end and a cathode end, the capillary array provided in a housing further comprising a reservoir configured to house a separation medium and an anode buffer. The system can also comprise an injection mechanism configured to deliver sample to the cathode end of the capillary array, and a temperature control zone, wherein the temperature control zone is configured to control the temperature of the interior of the housing.

Capillary array cartridge for capillary electrophoresis systems

The invention provides devices, systems, and methods for extracting target objects from a sample. In the method, a stream of sample containing a plurality of target and non-target objects is directed by first and second streams of buffer through a sample inlet channel into a fluid junction and through the fluid junction into a sample waste channel. In response to detecting a target object within the stream of sample, an actuator is energized to close a normally open valve, resulting in a transient burst of cross-flow into the fluid junction that briefly diverts the flow of sample within the fluid junction and results in an aliquot of sample being directed into an aliquot delivery channel. The combination of the valve and the actuator acts as a self-limiting pulse generator.

Device and method for extracting target objects from a sample

The invention provides fluidic devices having incorporated electrodes. One device comprises a card and first and second caddy segments. The first caddy segment comprises first and second electrodes. The second caddy segment comprises first and second reservoirs disposed on a first surface of the second segment, a channel disposed on a second surface of the second segment, and first and second vias extending between the first and second surfaces. The first caddy segment is attached to the first surface of the second caddy segment. The card is attached to the second surface of the second caddy segment such that the card provides a closed surface for the device.

Fluidic devices having incorporated electrodes

The invention provides fluidic devices having incorporated electrodes. One device comprises a card and a caddy. The card includes a channel disposed within the card, first and second vias in fluid communication with the channel through an upper surface of the card, and first and second electrodes disposed on the upper surface of the card. The first via and first electrode are positioned adjacent to a first end of the channel, and the second via and second electrode are positioned adjacent to a second end of the channel. The caddy comprises first and second reservoirs. The caddy is attached to the card such that the first reservoir is positioned over the first via and a portion of the first electrode, and the second reservoir is positioned over the second via and a portion of the second electrode. A portion of each of the electrodes is accessible for dry electrical contact.

Method and system for obtaining and using observed market rates in estimating suitable market-based compensation for one or more jobs. Each observed market rate is assigned a job family and a combination of a job category and a job level of responsibility (C/L). Median market rates and average market rates are observed for different job families and are combined in a novel way to produce job family factors and C/L factors that, when multiplied together accurately reflect market rates for that job, even for a combination of job family and job C/L that is not represented in the data.

Market pay system

Growing community of inventors

San Francisco, CA, United States of America

Alexander V Dukhovny