Albany Molecular Research, Inc.

Harmony Biosciences, Inc.

Curia Global, Inc.

Alexander Usyatinsky

Peter Guzzo

Matthew Surman

May Xiaowu Jiang

Alan John Henderson

Mark Hadden

James Grabowski

Matthew David Surman

Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein Ris H or optionally substituted alkyl; R, R, Rare each independently selected from H, &#x2014;O-alkyl, &#x2014;S-alkyl, alkyl, halo, &#x2014;CF, and &#x2014;CN; G is &#x2014;CRR&#x2014;NR&#x2014; or &#x2014;NR&#x2014;CRR; Ris H, optionally substituted alkyl, optionally substituted heterocycle, &#x2014;C(&#x2550;O)&#x2014;R, &#x2014;C(&#x2550;O)&#x2014;O&#x2014;R, or &#x2014;C(&#x2550;O)&#x2014;NRR; Rand Rare each optionally substituted alkyl or optionally substituted heterocycle; R, R, R, R, R, R, Rand Rare each independently selected from H or optionally substituted alkyl; Rand Rare each independently H or halogen; L is &#x2014;CH&#x2014;O&#x2014;, &#x2014;CHCH&#x2014;, &#x2014;CH&#x2550;CH&#x2014; or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.

(1-azinone)-substituted pyridoindoles

Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein Ris H or optionally substituted alkyl; R, R, Rare each independently selected from H, &#x2014;O-alkyl, &#x2014;S-alkyl, alkyl, halo, &#x2014;CF, and &#x2014;CN; G is &#x2014;CRR&#x2014;NR&#x2014; or &#x2014;NR&#x2014;CRR; R; is H, optionally substituted alkyl, optionally substituted heterocycle, &#x2014;C(&#x2550;O)&#x2014;R, &#x2014;C(&#x2550;O)&#x2014;O&#x2014;R, or &#x2014;C(&#x2550;O)&#x2014;NRR; Rand Rare each optionally substituted alkyl or optionally substituted heterocycle; R, R, R, R, R, R, Rand Rare each independently selected from H or optionally substituted alkyl; Rand Rare each independently H or halogen; L is &#x2014;CH&#x2014;O&#x2014;, &#x2014;CHCH&#x2014;, &#x2014;CH&#x2550;CH&#x2014; or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.

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Troy, NY, United States of America

Alexander Usyatinsky