Csem Centre Suisse D'electronique Et De Microtechnique Sa Recherche Et Developpement

I-property Holding Corp.

Csem Centre Suisse D'electronique Et De Microtechnique Sa

Abb Research Ltd.

Basf Se Corporation

Asea Brown Boveri Ag

At&s Austria Technologie & Systemtechnik Aktiengesellschaft

Nano-4-u Ag

Centre Suisse D'electronique Et De Microtechnique Sa—recherche Et Developpement

Csem Centre Suisse D'electrique Et De Microtechnique Sa—recherche Et Developpement

Alexander Stuck

Harald Walter

Philippe Bugnon

Raymond Zehringer

Peter Karl Steimer

Hans Reichert

Marc Schnieper

Stefan Klocke

Michelle Richert

Ross Stanley

Gregor Langer

Raphaël Pugin

Robert Beer

Markus Riester

Nicolas Blondiaux

Mark Robert Dicker

David R Boswell

Gilbert Gugler

Jürgen Söchtig

Toni Frey

Thomas Gering

Mickaël Guillaumee

Marc Pauchard

Hansruedi Zeller

Christian Zschokke

Paul Glendenning

Mark Schnieper

Ulrich Gubler

The present invention relates to a verification method of tablets, in particular pharmaceutical tablets. It further relates to an invisible secure marking or information which is a part of such tablet. The invention further relates to tablets suitable for such verification method, to processes for manufacturing such tablets and methods for reading the information.

Verification method

A simple and quick verification of the authenticity of a blister of elements, such as pills in the pharmaceutical industry, is provided. The pills packaged in a blister can be authenticated using mobile imaging devices such as a mobile smartphone. Generally speaking, an image of the pills and their differentiating physical characteristics in the blister is acquired and compared to at least one code which is marked on the blister itself. This code may also be encrypted. A dedicated software application on the mobile smartphone can be used to decrypt the code and compare the code to the image of the pills in the blister, to thereby evaluate authenticity of the blister and its contents.

Simple authentication of elements in blister packages

A solid pharmaceutical dosage form has micro- or nanostructures impressed on the surface thereof or an interface thereof. The dosage form includes a suitable quantity and distribution of ingredients, such as one or more dyes, so as to enhance the optical contrast effect caused by the micro- or nanostructures so that the micro- or nanostructures are observable by the human eye and thereby able to provide anti-counterfeiting characteristics to the dosage form.

Manufacturing solid pharmaceutical dosage forms with visible micro- and nanostructured surfaces and micro- and nanostructured pharmaceutical dosage form

A tablet for pharmaceutical use has on at least one part of its surface a diffractive microstructure which generates diffraction effects which can be perceived in the visible spectral range and which serve as visual safety feature. The tablet includes a plurality of individual powder particles, where the diffractive microstructures are impressed into the surface of the individual powder particles. A compression tool to produce such tablets has on one pressing surface of the compression tool micro-structures, where the microstructures have dimensions which are smaller than the dimensions of the individual crystallites of the material of the pressing surface of the compression tool. The micro-structures of the compression tool can be produced for example by ion etching or by imprinting.

Pharmaceutical tablets with diffractive microstructure and compression tools for producing such tablets

This inventive method assures the authenticity of drugs or other valuable substances that reside within product containers, such as syringes. The method includes initially measuring the 3D topology of the glass surface while determining the distance to the glass surface. Thereafter, a desired 3D code is written below the glass surface with a pulsed laser system. The written 3D code is readable using optical coherence topography (OCT) or parallel optical coherence tomography (pOCT) to verify the authenticity of the product container. A system uses this method with a plurality of syringes held within a tray, and a writing apparatus that moves relative to the tray to write a predetermined 3D code on each of the syringes held in the tray, during processing of the syringes along a process line while in the tray.

3D laser coding in glass

The present invention relates generally to an apparatus for embossing a flexible substrate. More specifically, the present invention relates to an apparatus for embossing a curable composition coated flexible substrate with an optically variable image transferred from an embossing foil, especially belt, or sheet of an optically transparent fluoropolymer. The optically variable image is irradiated through the embossing belt, or sheet with ultraviolet light contemporaneously with the embossing so that the transferred imprint pattern cures, hardens, and retains its shape.

Apparatus and method for a sub microscopic and optically variable image carrying device

The present invention discloses an isotropic optical filter comprising high-index refraction material positioned between low-index-refraction matter. At least some of the high-index refraction material has a grated structure and lateral and vertical dimensions with respect to the low-index-refraction matter such that the high-index refraction material is operative to act as a leaky waveguide for light incident on the ZOF. The grated structure comprises at least two different grating patterns. Each of the at least two grating patterns constitutes a subpixel. A plurality of subpixels is operative to diffract incident light to at least two zero-order wavelength spectra respective of the at least two grating patterns such to exhibit an isotropic color effect with respect to the rotational orientation of the isotropic optical filter. The plurality of subpixels constitute an isotropic pixel.

Isotropic optical filter and method of manufacturing thereof

The present invention relates to a method for the authentication of dosage forms such as tablets, in particular pharmaceutical tablets, by reading, i.e. detecting, code structure from the tablet, reading additional information from the package or on an information sheet, and then comparing the readings to verify authenticity. The code structure may be randomized on a plurality of tablets disposed in identifiable locations in a shared package such that the detected code structures define a unique digital signature for the package of tablets.

Method for the authentication of dosage forms

The present invention discloses a method for manufacturing a zero-order diffractive filter comprising a high-index material having an upper surface and a lower surface. The high-index material is positioned between a first low-index matter and a second low-index matter; the lower surface is adjacent to said first low-index matter and the upper surface is adjacent to the second low-index matter. Moreover, the high-index material has an index of refraction that is higher than the index of refraction of both said first low-index matter and said second low-index matter. The method comprises at least the following procedure: selectively providing, by employing at least one wet-coating technique, at least one of the following at least partially: the high-index material onto said first low-index matter.

Zero-order diffractive filter and method for manufacturing thereof

A sensor which reacts on influences from an environment. The sensor includes a zero-order diffractive color filter. The zero-order diffractive color filter includes a high-index waveguide layer, a zero-order diffractive grating structure and a layer of an reactive material, wherein the reactive material is in contact with the environment and wherein the reactive material changes its optical properties upon interaction with the environment. The reactive material is embedded in the waveguide layer and/or the reactive material is located at a maximum distance d from the waveguide layer. The distancing is effected by an intra layer having a low index of refraction.

Optical environmental sensor and method for the manufacturing of the sensor

A security device including a zero order diffractive microstructure buried within a substrate. One or more optical structures, such as microlenses, may be formed on a surface of the substrate. The optical structures modify the optical characteristics of the zero order diffractive microstructure. Various alternatives or additional optical structures and methods of producing the security device are described in additional embodiments.

Security device with a zero-order diffractive microstructure

The present invention relates to a verification method for tracking and tracing tablets, particularly pharmaceutical tablets. It further relates to a visible secure marking or information that is a part of such tablet (). The invention further relates to tablets suitable for such verification method, processes for manufacturing such tablets, and methods for reading the information.

Secure tracking of tablets

A method of tracking and tracing tablets, in particular pharmaceutical tablets, includes reading, i.e. detecting, code structure from the tablet, reading additional information from the package on an information sheet, and then comparing the readings to verify authenticity. The code structure may be two-dimensional or three-dimensional. The detected code may further be compared with information stored in a database.

The present invention relates to an isotropic zero-order diffractive color filter, to a method to manufacture an embossing tool and to a method to manufacture such a filter. The zero-order diffractive color filter comprises diffractive microstructures and a wave-guiding layer, wherein the diffractive microstructures possess a short range ordering over at least four times the period of the microstructures, and the diffractive microstructures possess a long range disordering over length scales of more than 100 &#x3bc;m.

Isotropic zero-order diffractive filter

A security Device comprises a zero order diffractive microstructure () buried within a substrate (). One or more further optical structures, such as microlenses (), may be formed on a surface () of the substrate (). The further optical structures modify the optical characteristics of the zero order diffractive microstructure (). Various alternatives or additional optical structures and methods of producing them are described in additional embodiments.

Growing community of inventors

Wettingen, Switzerland

Alexander Stuck