Sync-rx Ltd.

Dermagenesis, LLC

Vuze Medical Ltd.

Synx-rx, Ltd.

Alexander Steinberg

Ran Cohen

David Tolkowsky

Eldad Klaiman

Sagiv Philipp

Zohar Barzelay

Yoav Stein

Nili Karmon

Sarit Semo

Tianning Xu

Richard Vogel

Tony Xu

Jacob Blank

Apparatus and methods are described for use with an imaging device () configured to acquire a set of angiographic images of a lumen. At least one processor () includes blood-velocity-determination functionality () that determines blood velocity within the lumen, via image processing. Current-flow-related-parameter-determination functionality () determines a value of a flow-related parameter at the location based upon the determined blood velocity. Flow-related-parameter-receiving functionality () receives an indication of a value of a second flow-related parameter of the subject, and index-determination functionality () determines a value of a luminal-flow-related index of the subject at the location, by determining a relationship between the value of the current flow-related parameter and the value of the second flow-related parameter. Other applications are also described.

Determining a characteristic of a lumen by measuring velocity of a contrast agent

Apparatus and methods are described including a processor () configured to receive first and second sets of extraluminal images of a lumen, the second set being acquired while an endoluminal device is being moved through the lumen. The processor designates at least one of the first set of images as a roadmap image, and designates, within the lumen in the roadmap image, a roadmap pathway (). A plurality of features () that are visible within at least some of the second set of extraluminal images are identified, and an arrangement of three or more of the features within the image are compared to a shape of at least a portion of the roadmap pathway. Based upon the comparing, the identified features are mapped to locations along the roadmap pathway within the roadmap image. Other applications are also described.

Apparatus and methods for mapping a sequence of images to a roadmap image

Apparatus and methods are described including, using a computer processor, automatically identifying whether a given pixel within an image corresponds to a portion of an object. A set of concentric circles that are disposed around the pixel are sampled, and a first function is applied to each of the circles such that the circles are defined by a first set of rotationally invariant descriptors. A second function is applied to the set of circles to generate a second set of descriptors, each of which represents a difference between respective pairs of the circles. A third function is applied such that the second set of descriptors becomes rotationally invariant. The processor identifies whether the given pixel corresponds to the portion of the object, based upon the first and second sets of rotationally invariant descriptors. Other applications are also described.

Object identification

Apparatus and methods are described including acquiring 3D image data of a targeted skeletal portion within a body of a subject, and a 2D radiographic image of the targeted skeletal portion. A machine-learning engine is used to generate machine-learning data based on (i) the 3D image data of the targeted skeletal portion, (ii) a database of 2D projection images generated from the 3D image data, and (iii) respective values of one or more viewing parameters corresponding to each 2D projection image. A computer processor receives the machine-learning data, receives the 2D radiographic image of the targeted skeletal portion, and registers the 2D radiographic image to the 3D image data by using the machine-learning data to find a 2D projection from the 3D image data that matches the 2D radiographic image of the targeted skeletal portion. Other applications are also described.

Apparatus and methods for use with image-guided skeletal procedures

Apparatus and methods are described for use with a tool that is inserted into a portion of a body of a subject that undergoes cyclic motion. The apparatus and methods include using an imaging device, acquiring a plurality of images of the tool inside the portion of the body, at respective phases of the cyclic motion. Using at least one computer processor, an extent of movement of the tool with respect to the portion of the body that is due to the cyclic motion of the portion of the body is determined. In response thereto, an output is generated that is indicative of the determined extent of the movement of the tool with respect to the portion of the body. Other applications are also described.

Identification and presentation of device-to-vessel relative motion

Apparatus and methods are described for imaging a tool inside a portion of a subject's body that undergoes motion. A plurality of image frames are acquired of the portion of the subject's body. The image frames are image tracked by (a) automatically identifying at least a feature of the tool in at least a portion of the image frames, and (b) aligning the tool in image frames of the portion of the image frames, based on the automatic identifying. The image-tracked image frames of the portion of the subject's body are displayed as an image stream. Other embodiments are also described.

Automatic stabilization of a frames of image stream of a moving organ having intracardiac or intravascular tool in the organ that is displayed in movie format

Apparatus and methods are described for use with a plurality of angiographic image frames of a moving lumen of a subject, including aligning the image frames with each other. Using the aligned image frames, a time it takes a contrast agent to travel a known distance through the lumen is determined. At least partially in response thereto, a characteristic of the lumen is determined, and, in response to the determined characteristic, an output is generated on a display. Other applications are also described.

Apparatus and methods are described for use with an imaging device () configured to acquire a set of angiographic images of a lumen. At least one processor () determines blood velocity within the lumen, via image processing. The processor determines a value of a flow-related parameter at the location based upon the determined blood velocity. The processor additionally receives an indication of a value of a second flow-related parameter of the subject, and determines a value of a luminal-flow-related index of the subject at the location, by determining a relationship between the value of the current flow-related parameter and the value of the second flow-related parameter. Other applications are also described.

Determining a luminal-flow-related index using blood velocity determination

Apparatus and methods are described for use with an endoluminal data-acquisition device configured to be moved through a lumen of a subject's body, and a two-dimensional angiographic image of the lumen. A value of a luminal-flow-related index of the subject is determined non-invasively at a plurality of locations along the lumen, at least partially by performing image processing on the angiographic image. While the endoluminal data-acquisition device is being moved through the lumen, a set of endoluminal data points of the lumen at a plurality of locations within the lumen is acquired, using the endoluminal data-acquisition device. It is determined that respective endoluminal data points correspond to respective locations along the lumen, and, in response thereto, it is determined that respective endoluminal data points correspond to respective values of the luminal flow-related index. Other applications are also described.

Coregistration of endoluminal data points with values of a luminal-flow-related index

With inventive processing making use of surface-reconstruction and capping steps, more imagery acquired by 3C cameras can be put to use in augmented reality applications, especially applications, such as medical reconstruction, in which a certain theoretical ideal fit might be wanted but can be difficult or seemingly impossible to achieve due to highly complex, irregular shapes, perimeters and surfaces involved. The inventive technology is especially useful for ongoing wound measurement and comparative analysis and characterization of a wound over time, as well as working with anatomical reconstruction. The inventive technology also extends to non-medical augmented reality applications, and provides robust data sets representing a range of real-world objects, such as zoo animals, family pets, etc. susceptible of being imaged and stored as robust data sets that provide better verisimilitude when used in gaming or other virtual-world contexts as compared to a raw data set from a camera.

Methods of using an imaging apparatus in augmented reality, in medical imaging and nonmedical imaging

With the inventive technology, wound measurement is performed, but without the patient wound, or the skin near the patient wound, needing to have an object physically placed thereon. The patient wound and patient skin near the wound are spared contact with a ruler, marker, grid, and spared the wound and area near the wound being directly physically worked-on.

Touchless wound measurement, wound volume measurement, and other wound measurement

Apparatus and methods are described for receiving into at least one processor a set of images of blood vessels of a subject. A road map of the subject's blood vessels is generated, by automatically (a) deriving at least one image from the set of images of the blood vessels, based upon visibility of at least a portion of the blood vessels in the set of images, and (b) in the derived image, determining a location of edge lines of at least some of the portion of the blood vessels in the image. An output is generated by the processor, based on the road map. Other embodiments are also described.

Automatic generation and utilization of a vascular roadmap

Apparatus and methods are described including, while an endoluminal data-acquisition device is being moved through a lumen of a subject, acquiring a plurality of endoluminal data points of the lumen using the endoluminal data-acquisition device. It is determined that, at least one location, no endoluminal data point was acquired. An output is generated using at least a portion of the plurality of endoluminal data points of the lumen acquired using the endoluminal data-acquisition device, the output including an indication that no endoluminal data point was acquired at the location. Other applications are also described.

Accounting for skipped imaging locations during movement of an endoluminal imaging probe

Apparatus and methods are described, including, using an imaging device, acquiring a plurality of images of a portion of a body of a subject. Using a processor, a first feature within each of the images is aligned. At least one enhanced image that is enhanced with respect to the first feature is generated, using the aligned images. Visibility of a second feature is reduced in the enhanced image, and the at least one image that is enhanced with respect to the first feature is displayed upon a display. Other applications are also described.

Growing community of inventors

Raanana, Israel

Alexander Steinberg