Universitat Basel

Torqur Ag

Piqur Therapeutics Ag

Alexander Sele

Paul Hebeisen

Florent Beaufils

Denise Rageot

Jean-Baptiste Langlois

Matthias Wymann

Vladimir Cmiljanovic

Thomas Bohnacker

Doriano Fabbro

Petra Hillmann-Wüllner

Wolfgang Löscher

Hoa Huu Phuc Nguyen

Claudia Brandt

The present invention is relates to a compound of formula (I),

Treatment of neurological disorders

The invention relates to novel phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR) and PI3K-related kinase (PIKKs) inhibitor compounds of formula (I), wherein X, Xand Xare N or CH, with the proviso that at least two of X, Xand Xare N; Y is N or CH, These compounds are useful, either alone or in combination with further therapeutic agents, for treating disorders mediated by lipid kinases.

Difluoromethyl-aminopyridines and difluoromethyl-aminopyrimidines

The invention relates to novel phosphoinositide 3-kinase (PI3k), mammalian target of rapamycin (mTOR) and PI3k-related kinase (PIKKs) inhibitor compounds of formula (I), wherein X, Xand Xare N or CH, with the proviso that at least two of X, Xand Xare N; Y is N or CH, These compounds are useful, either alone or in combination with further therapeutic agents, for treating disorders mediated by lipid kinases.

Growing community of inventors

Basel, Switzerland

Alexander Sele