Biotronik Ag

Biotronik Vi Patent Ag

Litronik Entwicklungs Gmbh

Biotronik Mess-und Therapiegeraete Gmbh Ingeniurbuero Berlin

Cortronik Gmbh

Alexander Rzany

Wilhelm Erdbruegger

Alexander Borck

Robert Schmiedl

Bernhard Hensel

Bodo Gerold

Claus Harder

Matthias Fringes

Matthias Gratz

Nina Lehenberger

Hermann Kalb

Nina Foh

Ullrich Bayer

Heinz Mueller

Klaus-Peter Schmitz

Jens Gobrecht

Detlef Behrend

Bjoern Klocke

Dimos Poulikakos

Bernd Pretzlaff

Max Schaldach, Jr

Jens Ulmer

Aldo Ferrari

Carsten Momma

Vartan Kurtcuoglu

Matteo Astorino

Giuseppe Pisani

Nicolas Bartilla

Philipp Schoen

Eric Wittchow

Tobias Kissling

Tina Pieger

Tobias Igelspacher

Christine Mueller

Daniel Niopek

Davide Mogentale

Kilian Badrutt

Martin Thoebe

Angela Podssun-Soldan

Heinz MÜLLER

Verena Andree

Wilhelm ERDBRÜGGER

Björn Klocke

Philipp Schön

Judith Flore Solowiej

A method for preparing tissue, in particular pericardial tissue, in particular for a heart valve prosthesis, the method including: decellularizing the tissue; subjecting the decellularized tissue to a cross-linking solution including glutaraldehyde; subjecting the tissue to a shape- and structure-stabilizing step, in which the tissue is exposed to a first solution containing glycerol and is exposed to a second solution containing polyethylene glycol; and drying the tissue after the shape- and structure-stabilizing step.

Method for reducing paravalvular leaks with decellularized tissue

A method of preparing biological tissue for use as a component of an implant, in particular as part of a vascular implant, more particularly as part of a heart valve prosthesis, which can be implanted by a catheter. The biological tissue is decellularized using a detergent, which includes surfactin and deoxycholic acid (DCA).

Method for the preparation of biological tissue for dry use in an implant

Medical material and a method for preparing a biological tissue for a medical application are provided. The material is useful as a sealing element in a heart valve prosthesis. A method includes decellularizing the biological tissue by decellularizing solution to obtain an acellular extracellular matrix, solubilizing the extracellular matrix of the biological tissue, and crosslinking collagen fibers of the solubilized extracellular matrix.

Medical material and method for preparing from biological tissue

An implant has a support structure (e.g., alloplastic) such as a stent or a scaffold, and a functional element (e.g., a heart valve) including or made of bacterial cellulose. At least a part of the support structure is embedded in the functional element or in an extension thereof so as to connect the functional element to the structural element via positive fit.

Medical implant with seamlessly connected bacterial cellulose

A method forms an implant with a base body made of a biocorrodible magnesium alloy. The methods make magnesium alloy that contains a plurality of statistically distributed particles, with one or more of the elements Y, Zr, Mn, Sc, Fe, Ni, Co, W, Pt and noble earths with the atomic numbers 57 to 71, or the particles comprise alloys or compounds containing one or more of the elements mentioned. The mean distance of the particles from each other is smaller than the hundredfold mean particle diameter.

Method for producing biocorrodible magnesium alloy implant

A method for preparing tissue, in particular pericardial tissue, in particular for use as a sealing means for a heart valve prosthesis for paravalvular leaks, characterised in that the tissue, in particular pericardial tissue, is decellularized (), subjected to a cross-linking () with a glutaraldehyde-containing solution, and subjected to a shape- and a structure-stabilising step (). The invention also relates to a heart valve prosthesis.

A method for preparing tissue for medical applications, including decellularizing the tissue by means of a detergent, characterized in that the decellularizing detergent contains at least one amphiphilic lipopeptide; treating the decellularized tissue with an &#x3b1;-galactosidase; and cross-linking the collagen fibers of the treated tissue by means of a suitable cross-linking agent.

Method for preparing biological tissue

A method of preparing biological tissue for use as a component of an implant, in particular as part of a heart valve prosthesis, which can be implanted by catheter. The biological tissue is subjected to a dimensional and structural stabilization step and is dried. For the dimensional and structural stabilization, a combination of a first, polyethylene glycol-containing solution and at least one second, glycerol-containing solution is used.

One embodiment of the invention relates to an implant comprising a base body made of a biocorrodible magnesium alloy. The magnesium alloy contains a plurality of statistically distributed particles, comprising one or more of the elements Y, Zr, Mn, Sc, Fe, Ni, Co, W, Pt and noble earths with the atomic numbers 57 to 71, or the particles comprise alloys or compounds containing one or more of the elements mentioned. The mean distance of the particles from each other is smaller than the hundredfold mean particle diameter.

Biocorrodible magnesium alloy implant

The invention relates to an implant comprising an active-agent-containing coating which covers the implant at least in sections. The coating is composed of at least two subsections; a first subsection contains the at least one active substance, and a second subsection contains an auxiliary agent.

Implant comprising an active-agent-containing coating covering the implant at least in sections

A method for preparing tissue for medical applications, in particular tissue for use for an artificial heart valve, wherein the method has the steps of decellularizing the tissue by means of a detergent and subsequently cross-linking the collagen fibers of the tissue by means of a suitable cross-linking agent. At least one lipopeptide, such as surfactin, for example, is used as the detergent for decellularization.

An aluminum electrolytic capacitor including an anode electrode, and a method for producing the anode electrode. The method includes providing an aluminum electrolyte including an ionic liquid and an aluminum salt, galvanically deposing an aluminum on an aluminum foil formed from the aluminum electrolyte, and anodically oxidizing a surface of the aluminum foil. The ionic liquid includes a pyrrolidinium cation and a halogenide. The aluminum electrolyte includes 50-70 mol. % of the aluminum salt based on a total substance amount of the ionic liquid and the aluminum salt. The galvanic deposition includes and is based on a deposition temperature ranging from 20&#xb0; C. to 100&#xb0; C., a current density ranging from 1 to 100 mA/cm, an applied potential ranging from &#x2212;0.1 V to &#x2212;1.0 V based on a potential of an aluminum reference electrode, and a deposition rate ranging from 1 to 50 &#x3bc;m/h.

Anode electrode for aluminum electrolytic capacitor and respective production method

The present invention refers to an implant with a surface layer having a topographic modification. The topographic modification includes a line pattern with ridge and groove widths of 0.9 to 1.1 &#x3bc;m and a ridge height of more than 0.9 &#x3bc;m.

Implant with a surface layer having a topographic modification

The invention relates to an implantation device (-) comprising at least one medical implant (-) and at least one implantation aid (-) comprising at least one expansion element (-). It is provided that the expansion element (-) can be inserted into at least one cavity (-) of the implant (-), and the at least one cavity (-) can be expanded using the expansion element (-), and, in the end state, the expansion element (-) is disposed at least partially in the at least one cavity (-), wherein the expansion element (-) is designed as a solid body (-).

Implantation device

A method for producing an implant, particularly an intraluminal endoprosthesis, having a body, wherein the body comprises magnesium or a magnesium alloy. In order to control the degradation in a desired time window, such as between four weeks and six months, the following production method is carried out: a) preparing the implant body, b) applying a metallic coating onto at least a portion of the body surface, the primary constituent of the coating being at least one element of the group containing titanium and aluminum, c) plasmachemical treatment of the portion of the body surface provided with the coating in an aqueous solution in order to produce a layer created by plasmachemical treatment by applying a mixed voltage generating the plasma to the body of the implant, wherein the mixed voltage has sufficient energy to temporarily ionize both the metallic coating and a subjacent region of the implant body. The invention further relates to an implant that can be obtained by such a method.

Implant and method for producing the same

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Nuremberg, Germany

Alexander Rzany