Miles Inc.

Miles Laboratories, Inc.

Riebel, Alexander

Oosta, Gary

Himmelmann, Wolfgang

Sobel, Johannes

Schranz, Karl

White, William

Alexander Riebel

Karl Schranz

Karl W Schranz

Gary Oosta

Wolfgang Himmelmann

Helmut Reiff

Gunter Helling

Karl-Wilhelm Schranz

Karlheinz Hildenbrand

Bernhard Schulte

Klaus Wehling

Claus Burkhardt

Werner Kroll

Walther Cohnen

Thomas Doege

Philip R Strom-Jensen

Peter Doppelfeld

William White

Johannes Sobel

The present invention is directed to the use of polymer blend films consisting of polycarbonate and polyalkylene terephthalate supports for diagnostic test strips.

Use of polymer blend films as supports for diagnostic test strips

Process for the preparation of stable dispersions of hydrophobic reagents in aqueous material, which process involves dissolving an ionomeric polymer, together with hydrophobic reagent substance, in a suitable organic solvent, adding water to the resulting material and then removing the organic solvent. The resulting dispersion has exceptionally high stability and finds utility in the production of diagnostic reagent test devices.

Process for the preparation of reagent layers containing hydrophobic

The present invention relates to a process for troublefree, i.e. flaw-free and uniform, coating of a support which can accept a large amount of electrostatic charge, such as, for example, polycarbonate foils, with a solution of fully reacted polyurethane in organic solvents, more precisely after prior coating of the polycarbonate foil with an organic solution of the sodium salt of polystyrenesulphonic acid.

Process for troublefree coating of hydrophobic materials with

Proteins such as enzymes are attached directly to a polyamide or cellulose hydrate carrier. Attachment can be carried out by impregnation of the carrier with a protein solution. The carrier can be in the form of a membrane, and the polyamide can be nylon. Resulting carrier-bound proteins find utility as biocatalyst, as test strips or as chromatography materials. In a preferred embodiment, a polyamide or cellulose hydrate membrane carrier is impregnated with an enzyme selected from peroxidase, glucose oxidase, diaphorase and glucose dehydrogenase and then dried, coated with a luminol solution and again dried. The resultant membrane can be used for glucose determination by measuring chemiluminescence produced when the membrane contacts a glucose solution.

Enzymes immobilized on polyamides or cellulose hydrate

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Leverkusen, Germany

Alexander Riebel