Sealife Pharma Gmbh

Marinomed Biotech Ag

Marinomed Biotechnologie Gmbh

Alexander Pretsch

Michael Nagl

Christoph Wiesner

Andreas Grassauer

Eva Prieschl-Grassauer

Ralph Hollaus

Christiane Koller

Miroslav Genov

Heinz Burgmann

Peter Proksch

Christiane Meier

Abdessamad Debbab

Polyguanidines and methods of use thereof are described. In particular, polyguanidines of formula (I), formula (II), and formula (III) are described. The polyguanidines can be used to treat infection, such as bacterial, viral or fungal infection, and as an ex vivo microbial agent. 

Polyguanidine polymers and methods of use thereof

Disclosed herein is a method of reducing the risk of a rhinovirus infection, the method includes administering to a subject a composition comprising iota-carrageenan in an antiviral effective amount as an active antiviral ingredient.

Antiviral composition and method of use

A method for preparing polycondensation products of guanidine, aminoguanidine or diaminoguanidine G with one or more benzyl or allyl derivatives BA according to the following reaction scheme is provided: wherein X, R, Gua, Y and Z are as defined in the specification. In the disclosed method, at least one benzyl or allyl derivative BA is subjected to a polycondensation reaction with excessive guanidine, aminoguanidine or diaminoguanidine G upon elimination of HX.

Method for producing polyguanidines

Polycondensation products of aminoguanidine and/or 1,3-diaminoguanidine with one or more diamines are provided including polyguanidine derivatives of the following formula (I) or a salt thereof: wherein X is selected from &#x2014;NH, aminoguanidino and 1,3-diaminoguanidino; Y is selected from &#x2014;H and &#x2014;R&#x2014;NH; or X and Y together represent a chemical bond to give a cyclic structure; Ris selected from divalent organic radicals having 2 to 20 carbon atoms, in which optionally one or more carbon atoms are replaced by O or N; a and b are each 0 or 1, wherein a+b&#x2260;2 if no 1,3-diaminoguanidine units are included; Ris selected from &#x2014;H and &#x2014;NH, wherein Ris &#x2014;NHif a+b=0, Ris &#x2014;H or &#x2014;NHif a+b=1, and Ris &#x2014;H if a+b=2; and n&#x2267;2. Production methods and uses of the polyguanidine derivatives are also provided.

Bioactive polymers

A method for manufacturing an antiviral pharmaceutical composition for the prophylaxis or treatment of a rhinovirus infection that includes the utilization of iota-, kappa- or lambda-carrageenan or mixtures thereof.

Growing community of inventors

Großmugl, Austria

Alexander Pretsch