The Brigham and Women's Hospital, Inc.

The Charles Stark Draper Laboratory, Inc.

Children's Medical Center Corporation

Alexander P Lin

Carolyn Mountford

John M Irvine

Laura Jane Mariano

Saadallah Ramadan

Susan Waisbren

Robert Stern

A method and a system for analysis of raw MRS data, in the form of signal strength versus chemical shift (ppm), from multiple scanners, includes 'signal estimation' from each raw data set, followed by cross-scanner 'data harmonization' of results. The final resulting MRS signals are consistent from one scanner to another, and are used for analysis by radiologists and other physicians.

Method and procedure for signal estimation and data harmonization for magnetic resonance spectroscopy (MRS)

Systems and methods for analyzing metabolite concentration in a subject using a medical imaging system are provided. The method includes, using a nuclear magnetic resonance (NMR] system, acquiring data from a subject during multiple acquisitions using different echo times for the multiple acquisitions to create a chemical shift domain. The method also includes, using the chemical shift domain, identifying metabolites by at least two chemical shifts and generating a report indicating the metabolites.

System and method for locally correlated spectroscopy for assessing medical discorders

A method for producing a biomarker indicative of a repetitive head injury in a subject using a magnetic resonance imaging (MRI) system is provided. Two-dimensional spectroscopic data is acquired from a subject using an MRI system. From the two-dimensional spectroscopic data, a two-dimensional spectrum is produced. The two-dimensional spectrum contains spectral information indicated by a first spectral dimension and a second spectral dimension. Such a two-dimensional spectrum may include diagonal peaks and off-diagonal, or cross-peaks. In such an instance, each cross peak may indicate, for example, scalar coupling between the two protons it connects on the diagonal. However, depending on the type of method used, different types of coupling may also be present. Using the two-dimensional spectrum, a biomarker indicative of repetitive head injury in the subject is identified, and may be used to produce a report indicating a status or regression of a neurological dysfunction.

Method for assessing repetitive head injuries with two-dimensional magnetic resonance spectroscopy

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Boston, MA, United States of America

Alexander P Lin