Zymergen Inc.

Alexander Neckelmann

Jeffrey Kim

Oliver Liu

Zachariah Serber

Jennifer Shock

William W Hwang

Xiao Yang

Sangita Ganesh

Stephanie Leanne Brown Hendrix

Eyal Akiva

Samuel Oteng-Pabi

Claus Pelikan

Tom Hayon Eyles

Devin Scannell

Ute Galm

Michael Sneddon

Shawn Manchester

The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs). In some embodiments, the present disclosure also teaches methods for producing sequenced and assembled metagenomic libraries that are amenable to MGC search bioinformatic tools and techniques.

Metagenomic library and natural product discovery platform

The present disclosure provides methods and systems for identifying natural product-encoding multi-gene clusters (MGCs). In some embodiments, the present disclosure also teaches methods for producing sequenced and assembled metagenomic libraries that are amenable to MGC search bionformatic tools and techniques.

The present disclosure describes methods for generating microbial strains expressing a heterologous bacterial hemoglobin gene that produce biomolecules of interest. In aspects, the disclosure provides novel bacterial strains, which express a heterologous bacterial hemoglobin gene whose expression is controlled by a nativepromoter or a mutant promoter derived therefrom. Also provided herein are methods for producing a library of bacterial hemoglobin genes using a promoter ladder comprising a plurality of promoters derived from

Methods for generating a bacterial hemoglobin library and uses thereof

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Berkeley, CA, United States of America

Alexander Neckelmann