Rich Technologies Holding Company, LLC

Alexander N Shumeev

Ilya Ilyin

Stanislav A Kolchanov

Semyon Kogan

William E Grieshober, Jr

James S Jones

Igor Kachko

Yuriy Punin

Yana A Filkina

Natella I Enukashvily

Jr Grieshober William E

Vladimir Vasiliev

Mark Bakhrakh

Yuri Punin

William E Grieshober

A method for platelet preservation comprising placing a composition comprising platelets in a gas mixture comprising xenon and oxygen under pressure of about 0-10 Bars at a first temperature of about 18&#xb0; C.-37&#xb0; C. for a first period of time, and then subsequently cooling the composition to a second temperature of about 0,1&#xb0; C.-6&#xb0; C., and holding the composition under the pressure and in the second temperature for a second period of time.

Method for living tissue preservation

Provided is a method for reducing apoptosis in nucleated cells. The method entails holding nucleated cells in a container and adding a gas containing xenon to the container so that the pressure inside the container reaches between 0.5 to 4.0 Atm above ambient pressure; holding the container at between 0.5 to 4.0 Atm above ambient pressure for a period of time during which the temperature in the container is between 22&#xb0; C. and 37&#xb0; C.; lowering the temperature in the container to between 0.1&#xb0; C. and 10&#xb0; C. while maintaining the pressure of 0.5 to 4.0 Atm above ambient pressure and holding the container for a period of time; and reducing the pressure in the container to ambient pressure and increasing the temperature to 22&#xb0; C.-37&#xb0; C. By performing these steps, the cells undergo less apoptosis than a reference.

Method for preserving cells and cell cultures

A system, method, and device for preserving blood and its components is described. The system and method generally include a device having a body defining a chamber, the chamber being configured to receive at least one bag containing blood or its components, the at least one bag being permeable to gas, for example, xenon. A cover is hermetically sealable to the body. An inlet is in fluid communication with the chamber. A pressure indicator is configured to indicate pressure in the chamber, the pressure indicator including a conduit containing a liquid. A portion of the conduit is transparent such that the liquid is visible. A source of pressurized gas, such as xenon, is provided to provide the pressurized gas to the chamber.

System, method, and device for preserving blood or its components in gas medium under pressure

A method and a platelet concentrate preservation device for platelet concentrate storage. A method includes at least partially saturating platelet concentrate xenon, and storing the platelet concentrate at less than 15 C in a generally horizontal position. A device can be used to store blood, blood products, or combinations thereof that may or may not be under pressure. The device includes a chamber having a cavity. The chamber includes first and second chamber parts that form the cavity when releasably connected together. The cavity is designed to receive at least one bag that contains the blood, blood products, or combinations thereof. The device also includes a high-strength casing and includes a chamber cavity. The high-strength casing includes first and second casing parts that form the chamber cavity when releasably connected together. The chamber cavity is designed to receive the chamber.

Platelet concentrate preservation method

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St. Petersburg, Russia

Alexander N Shumeev