University System of Maryland

Innovo Biopolymers, LLC

Parallel Solutions, Inc.

Alexander Marin

Alexander K Andrianov

Thomas R Fuerst

Peter Fusco

Jonathan Sargent

Jiangping Chen

Polyphosphazenes polyelectrolytes. The polyphosphazenes can be prepared by substituting pendant groups (e.g., ionic groups or pendant groups that can form ionic groups) onto a reactive macromolecular precursor for example, by reaction between the reactive chlorine atoms on the backbone of poly(dichlorophosphazene) and appropriate organic nucleophiles. In certain examples, one or more charged pendant groups of a polyphosphazene is/are further modified to introduce desired counterions, which can be hydrophobic counterions. The polyphosphazenes can activate distinct Toll-Like Receptors (TLRs) and can be used in methods of stimulating an immune response.

Polyphosphazene polyelectrolytes and uses thereof

Provided are polyphosphazenes and methods of making and using the polyphosphazenes. The polyphosphazenes can be essentially chloride free. The polyphosphazenes can be phosphazene polyacids. The polyphosphazenes can be used as surface coatings, or as adjuvants when combined with antigens.

Polyphosphazenes, methods of making, and uses thereof

Biodegradable polyphosphazene polymers containing pyrrolidone side groups, and the biomedical use of such polyphosphazene polymers are disclosed.

Biodegradable polyphosphazenes containing pyrrolidone side groups

Polyphosphazene polymers having immunomodulating activity, and the biomedical use of such polyphosphazene polymers, in conjunction with an antigen or an immunogen are disclosed.

Immunostimulating polyphosphazene compounds

A polyphosphate polymer which includes both (i) ionic or ionizable moieties; and (ii) fluorine-containing moieties. Such polymers may be used as matrices for pharmaceuticals, as multilayer coatings for fuel cell membranes, as dopant for electrically conductive polymers, or as multilayer coatings for biomedical devices.

Polyphosphazenes including ionic or ionizable moieties and fluorine-containing moieties

Polyphosphazene polymers having at least one sulfonated pendent group, and no more than five different sulfonated pendent groups, repeated along the polymer chain, wherein at least one the repeated sulfonated pendent groups links at least one SOgroup to the polymer chain through a nitrogen-free linkage containing at least three carbon atoms, are disclosed, along with methods of making same, and uses therefor.

Growing community of inventors

Rockville, MD, United States of America

Alexander Marin