Depuy Synthes Products, Inc.

Ethicon, Gmbh

Advanced Technologies and Regenerative Medicine, LLC

Depuy Mitek, Inc.

Alexander M Harmon

Anna Gosiewska

Anthony J Kihm

Ian Ross Harris

Sanjay Mistry

Darin J Messina

Agnieszka Seyda

Chin-Feng Yi

Laura Brown

Sridevi N Dhanaraj

Julia Hwang

Stephanie M Kladakis

Carrie H Fang

Charles J Buckle

Frederick Halperin

Stanko Bodnar

L S Klaudyne Hong

Carri H Fang

Ziwei Wang

Abel Ang

Janet E Davis

Laura J Brown

Klaudyne L Hong

Anna Goseiwska

Klaudyne L S Hong

Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.

Cartilage and bone repair and regeneration using postpartum-derived cells

Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.

Postpartum cells derived from placental tissue, and methods of making and using the same

Cells derived from postpartum tissue and products thereof having the potential to support cells of and/or differentiate to cells of a soft tissue lineage, and methods of preparation and use of those postpartum tissue-derived cells, are provided by the invention. The invention also provides methods for the use of such postpartum-derived cells and products related thereto in therapies for conditions of soft tissue.

Soft tissue repair and regeneration using postpartum-derived cells and cell products

Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.

Postpartum cells derived from umbilical cord tissue, and methods of making and using the same

A stable and scalable process is provided to manufacture reduced serum umbilical cord tissue-derived (UTC)-conditioned media. The method includes the culture of a UTC under reduced serum conditions. Subsequently, the UTC is washed and grown in serum-free basal media. After approximately 24 hours, the conditioned media is collected, filtered and concentrated by use of an approximately 5 kDa or similar cut-off membrane.

Conditioned media and methods of making a conditioned media

Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.

Regeneration and repair of neural tissue using postpartum-derived cells

Cell-based compositions and methods of their use to inhibit an adverse immune response such as graft versus host disease or rejection of transplanted tissue in a transplant recipient that is histocompatibility mismatched to the transplant donor are disclosed. The compositions and methods utilize postpartum-derived cells, such as cells derived from the placenta or umbilicus.

Human umbilical cord tissue cells for inhibiting adverse immune response in histocompatibility-mismatched transplantation

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Clinton, NJ, United States of America

Alexander M Harmon