Hoffmann-la Roche Inc.

Roche Glycart Ag

Other

Bernd Mueller-beckmann

F. Hoffmann-la Roche Ag

Alexander Lifke

Birgit Bossenmaier

Gerhard Niederfellner

Ekkehard Moessner

Guy Georges

Hans-Willi Krell

Valeria Lifke

Johannes Auer

Georg Fertig

Sebastian Dziadek

Reiner Lammers

Christian Weilke

Lars Hillringhaus

Kairat Madin

Bernd Mueller-Beckmann

Tobias Schnitzer

Hans Willi Krell

The current invention is directed to a method for obtaining a nucleic acid encoding an immunoglobulin variable domain from a single cell comprising the following steps: &#x2014;performing a first polymerase chain reaction with three to six 5'-primer and one 3&#x2032;-primer, performing with the product of the first polymerase chain reaction a second polymerase chain reaction with thirteen to sixteen 5&#x2032;-primer and one 3&#x2032;-primer, whereby the distance of the binding locations of the primer employed in the second polymerase chain reaction is reduced compared to the first polymerase chain reaction.

Method for obtaining immunoglobulin encoding nucleic acid

The present invention relates to humanized antibodies against human CDCP1 (anti-CDCP1 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

Humanized anti-CDCP1 antibodies

The present invention relates to antibodies against human CDCP1 binding to the same epitope as CUB4 (Deposition No. DSM ACC2551) for the treatment of cancer.

Antibodies against CDCP1 for the treatment of cancer

The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.

Method for the production of antibodies

Growing community of inventors

Penzberg, Germany

Alexander Lifke