Pressure Biosciences, Inc.

Northeastern University

Aquatic Company

Alexander Lazarev

Edmund Y Ting

Vera Gross

Barry L Karger

Jun Ma

Richard T Schumacher

Thomas Rejtar

A high pressure valve includes a lever and a variable force generator for facilitating control of opening and closing the valve at high pressures. The high pressure valve includes a housing having a chamber providing fluid communication between a first port and a second port, a pin movable within the chamber between an open position and a closed position. A first end of a lever is coupled to the pin and a second end of the lever is coupled to a variable force generator. The lever pivots about a pivot point. A controller coupled to the variable force generator is configured to adjust a force applied to the second end of the lever by the variable force generator to control the movement of the pin between the open position and the closed position.

Ultrahigh pressure compact valve with throttling capability

Devices and methods for sample preparation via pressure cycling technology are disclosed. The device for sample preparation comprises a tube having an inner surface, a top, and a bottom, the tube configured to contain a sample at the bottom and to be received into a pressure chamber for sample preparation, a cap detachably connected to the top of the tube, and a tapered elongate member extending from the cap into the tube, the tapered elongate member configured to contact the inner surface of the tube and the sample in the bottom of the tube, wherein the tube is deformable such that in operation under pressure the tube is deformed against the tapered elongate member to promote disruption of the sample.

Sample preparation devices and methods

A pressurizable sample system includes a microplate having a planar plate surface and several sample wells. Each sample well has a flange positioned circumferentially around an outer surface of the sample well and against the planar plate surface. The sample system further includes a capping plate with a planar cap surface and several caps projecting from the planar cap surface. Each cap has a geometrical configuration in complementary correspondence with the configuration of the sample well.

System and method for microplate pressurization

Described herein is a sample preparation device including a sample delivery source, an inline means of transferring the sample from the sample source into a deformable channel within a pressure vessel, and out of the channel into downstream analysis components, a deformable channel disposed within the pressure vessel, the deformable channel having an inlet end and an outlet end fluidly connectable to high pressure valves and a means to measure the fluid pressure within the deformable channel, an external source of a controlled pressurized fluid fluidly connectable to the pressure vessel and a controller system that monitors and controls the sample fluid pressure by control of the external pressure vessel fluid.

Flow-through high hydrostatic pressure microfluidic sample preparation device and related methods therefor

Methods of extracting a component of interest from a plurality of components are described.

Extraction and partitioning of molecules

The present invention is related to systems and methods for chemical and biological analysis and, in particular, to systems, apparatus, and methods of sample conditioning and analysis.

High pressure sample containment system for electromagnetic measurements

A device and method to provide a simplified wash process and controlled disintegration of a soft substance, such as a gel, are disclosed. In use, a block of, e.g., gel matrix is placed in the device and washed with a series of appropriate solutions to remove interfering contaminants. The washing liquid is removed through a deformable narrow opening in the bottom of the device, and, subsequently, the gel block is extruded through the deformable narrow opening, by a physical force, such as centrifugal force, a vacuum or positive pressure from a gas or liquid, etc., resulting in fragmentation of the gel block into a series of particles of similar size. The fragmentation of the gel results from shear forces exerted onto the gel block traveling through the deformable narrow opening in the device. The rate of such fragmentation and resulting fragment size can be controlled by extruding the gel block using a predefined level of force as well as by controlling the dimensions and shape of the narrow opening (s) in the device.

Devices, methods and applications for extraction of molecules from polymeric gel electrophoretic media

A wireless transceiver for transmitting data across a pipe joint is described herein. At least some illustrative embodiments include a wireless communication apparatus including a housing configured to be positioned inside/proximate of/to an end of a drill pipe. The housing includes an antenna with at least one RF signal propagation path parallel to the axis of the housing, and an RF module (coupled to the antenna) configured to couple to a communication cable, and to provide at least part of a data retransmission function between an antenna signal and a communication cable signal. A material (transparent to RF signals within the RF module's operating range) is positioned along the circumference, and at/near an axial end, of the housing closest to the antenna. At least some RF signals, axially propagated between the antenna and a region near said axial end, traverse the radiotransparent material along the propagation path.

Growing community of inventors

Lexington, MA, United States of America

Alexander Lazarev