University of Virginia Patent Foundation

Alexander L Klibanov

John Alexander Hossack

Brian R Wamhoff

John C Herr

Kevin Simon Eisenfrats

Brent A French

Johnny Chen

Craig H Meyer

Kimberly A Kelly

F William Mauldin, Jr

Bruce D Gaylinn

Christopher M Kramer

Amit Patel

Shiying Wang

Leon S Farhi

George A Beller

David K Glover

Siva Sai Krishna Dasa

Dayuan Li

Lanthanide chelate lipid nanoparticles, and methods of their synthesis and use are described. Biological molecules labeled with the lipid nanoparticles, useful in bioaffinity assays with improved sensitivities are also described.

Compositions and methods for high-sensitivity immunoassays

Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.

Occlusive implant compositions

Isolated peptides targeting cardiovascular disease are described herein or one or more conservative amino acid substitutions, deletions or additions of such peptides and methods of use thereof for delivering payloads to specific cell types or tissues.

Target-specific delivery of therapeutic agents

A catheter system including an elongate tubular member having a proximal end portion, a distal end portion and a lumen extending through at least a portion of a length of the elongate tubular member. The distal end portion of the elongate member is dimensioned and adapted to advance to or in proximity to a treatment site of a subject. A microbubble device is in fluid communication with the lumen. The microbubble device includes at least one input port for receiving a flow of material into the device and an output port configured to output microbubbles from the microbubble device. A second tubular member is in fluid communication with one of the at least one input ports. A pressure fitting arrangement is adapted to maintain a seal between the second tubular member and the input port.

Systems and methods for ultrasound imaging and insonation of microbubbles

Methods for vas-occlusive contraception and reversal thereof

An ultrasound system and method that can include: a receive beamformer configured to receive signals from a transducer; a processor coupled to the receive beamformer, the processor configured to: analyze echo data reflected from a region of interest, the echo data elicited by a transmitted pulse sequence; using the echo data, determine a central tendency of a signal magnitude from regions of adherent microbubbles over time within the region of interest; determine a time series of the signal magnitude; using the time series, determine an initial signal magnitude parameter; obtain a saturated signal parameter and a residual signal parameter using the time series; and determine a relative indication of information indicative of the residual signal magnitude versus the saturated signal magnitude.

System and method for binding dynamics of targeted microbubbles

A method and related system for providing therapy to a treatment site, such as stenosis or other vasculature disease, at one or more locations of a subject, such as the vasculature. The method includes: advancing an ultrasound catheter to or in proximity to the subject's treatment site; infusing microbubbles into or proximal to the treatment site; and delivering ultrasonic energy from the ultrasound catheter. The ultrasonic energy may be adapted for: imaging the treatment site, translating the microbubbles into or in the vicinity of the treatment site and/or rupturing the microbubbles.

System for treatment and imaging using ultrasonic energy and microbubbles and related method thereof

The present invention provides multiple modalities for detecting LOX-1. More particularly, an imaging composition is provided that allows for the in vivo imaging of atherosclerotic plaque.

Multimodal imaging of atherosclerotic plaque targeted to LOX-1

Growing community of inventors

Charlottesville, VA, United States of America

Alexander L Klibanov