E.i. Dupont De Nemours and Company

Alexander L Johnson

Philip B Sweetser

William Brown Farnham

Ruth Richmond Wexler

Richard C Burns

Petrus B Timmermans

Philip Ma

1,4-Dihydropyridine derivatives which combine both calcium agonist and alpha.sub.1 -antagonist activity are useful in treating congestive heart failure. These derivatives are compounds having the formula: ##STR1## wherein Ar, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are defined in the specification.

1,4-dihydropyridine derivatives with calcium agonist and alpha.sub.1

Certain antihypertensive 1-substituted cyclic lactam-2-carboxylic acids and their derivatives are prepared by reacting an ester of the formula ##STR1## with a suitable derivative of the formula ##STR2##

Process for preparing antihypertensive 1-substituted cyclic

1-Substituted cyclic lactam-2-carboxylic acids and their derivatives are useful as antihypertensive agents.

Antihypertensive I-substituted cyclic lactam-2-carboxylic acids

A process for preparing nitroaromatic glycosides is described. The process comprises contacting an acetylated glycoside of maltotetraose, maltopentaose or maltohexaose with a phenol, nitrating the resulting product to place a NO.sub.2 group on the aromatic moiety and deacetylating the nitrated product. The nitroaromatic glycosides are useful as standard substrates for the assay of .alpha.-amylase.

Process for preparing nitroaromatic glycosides

Nitroaromatic derivatives of glycosides such as maltotetraose, maltopentaose and maltohexaose are described. These compounds are useful as standard substrates for the assay of .alpha.-amylase either manually or automatically on suitable instruments.

Nitro aromatic glycosides

Selected 1-(2-carboxyaryl)-4-arylimidazoles and 1-(2-carboxyaryl)-3-aryl-1,2,4-triazoles are useful in making buffer solutions; as picrate dyes; and as plant growth regulators. Exemplary are 1-(2-carboxyphenyl)-4-phenyl-imidazole and 1-(2-carboxyphenyl)-3-phenyl-1,2,4-triazole.

1-(2-Carboxyaryl)-3-aryl-1,2,4-triazoles and use as herbicides

Substituted pyrazole compounds have been found to be effective plant growth regulants. Exemplary of the effective compounds are 3-(2-carboxyphenyl)-5-phenyl-pyrazole, its 2-ethanolamine salt, and 3-(2-carboxy-1-cyclohexen-1-yl)-5-phenylpyrazole.

Pyrazole plant growth regulants

1-(2-Carboxyaryl)-4-arylimidazoles and

Substituted pyrazole compounds have been found to be effective plant growth regulants. Exemplary of the effective compounds are 3-(2-carboxyphenyl)-5-phenylpyrazole, its 2-ethanolamine salt, and 3-(2-carboxy-1-cyclohexen-1-yl)-5-phenylpyrazole.

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Wilmington, DE, United States of America

Alexander L Johnson