Liveleaf, Inc.

Percutaneous Systems, Inc.

Boston Scientific Scimed, Inc.

Radiotherapeutics Corporation

Takai Hospital Supply Co., Ltd.

Percutaneous Sustems, Inc.

Liveleaf Holdings, LLC

Huang, Alexander, L.

Wu, Gin

Percsys Secured Creditors, LLC

Takai Hospital Suppy Co., Ltd

Alexander L Huang

Gin Wu

Robert S Behl

Morton Grosser

Rupesh K Desai

Steven D Yee

Henry Lao

Linh A Dinh

Jennifer A Hodor

Peter F Lyons

David Needleman

Kenneth A Peartree

Sharon A Riddle

The present invention is directed to a method and a composition for producing and using a plant-based biocidal solution. The plant-based biocidal solution contains a bioactive material and a plant-based substance formed from the cellular material of a plant. The plant-based substance is capable of binding to the bioactive material. In some embodiments, the bioactive material is hydrogen peroxide. The hydrogen peroxide can be added exogenously or generated endogenously. In accordance with further embodiments, the plant-based biocidal solution can be applied to a target, thereby impairing the target. In some embodiments, the target can be a pathogen. In accordance with another embodiment, the plant-based substance of the plant-based biocidal solution can form a microscopic cluster, a complex, or an aggregate for providing sufficient bioactive material to overcome the defense mechanism of the target.

Method of increasing the half-life of hydrogen peroxide with polyphenols

Ingestible composition having hydrogen peroxide with an increased half-life

The present invention is directed to a method and a composition for producing and using a plant-based biocidal solution. The plant-based biocidal solution contains a bioactive material and a plant-based substance formed from the cellular material of a plant. The plant-based substance is capable of binding to the bioactive material. In some embodiments, the bioactive material is hydrogen peroxide. The hydrogen peroxide can be added exogenously or generated endogenously. In accordance with further embodiments, the plant-based biocidal solution can be applied to a target, thereby impairing the target. In some embodiments, the target can be a pathogen. In accordance with another embodiment, the plant-based substance of the plant-based biocidal solution can form a microscopic duster, a complex, or an aggregate for providing sufficient bioactive material to overcome the defense mechanism of the target.

Increasing the half-life of hydrogen peroxide in an ingestible composition

Methods of inhibiting the virulence of a pathogen to treat a gastrointestinal spasm in a subject, without killing the pathogen, are provided. The methods can include administering an effective amount of a formulation to treat the gastrointestinal spasm, the formulation having a tannin combined with a hydroxyl radical in a pharmaceutically acceptable excipient as a binding pair, the tannin releasing in an oxidized state from the hydrogen donor after oral administration of the formulation in the subject; wherein, the composition at least inhibits a gastrointestinal spasm in the subject when compared to a second subject in a control group in which the composition was not administered.

Methods of inhibiting the virulence of a pathogen with an oxidized tannin to treat a gastrointestinal spasm

Methods of treating a gastrointestinal spasm in a subject are provided. The methods can include administering an effective amount of a formulation to treat the gastrointestinal spasm, the formulation having a tannin combined with a hydrogen donor in a pharmaceutically acceptable excipient as a binding pair, the tannin releasing in an oxidized state from the hydrogen donor after oral administration of the formulation in the subject; wherein, the composition at least inhibits a gastrointestinal spasm in the subject when compared to a second subject in a control group in which the composition was not administered.

Methods of treating a treatment-resistant gastrointestinal spasm with an oxidized tannin

Methods of treating a treatment-resistant gastrointestinal spasm

Method of killing a bacteria with a plant-based biocidal solution

Methods of inhibiting bacterial virulence in a subject are provided. The methods can include administering an effective amount of a formulation to inhibit a bacterial virulence in a subject, the formulation having a water soluble tannin combined with hydrogen peroxide in a pharmaceutically acceptable excipient; wherein, the tannin has a molecular weight ranging from about 170 Daltons to about 4000 Daltons; the tannin:peroxide weight ratio ranges from about 1:1000 to about 10:1; and, the composition inhibits a bacterial virulence in the subject when compared to a second subject in a control group in which the composition was not administered.

Methods of inhibiting a bacterial virulence in a subject

Methods of treating gastro-esophageal reflux disease in a subject are provided. The methods can include administering an effective amount of a formulation to treat the gastroesophageal reflux disease, the formulation having a water soluble tannin combined with hydrogen peroxide in a pharmaceutically acceptable excipient; wherein, the tannin has a molecular weight ranging from about 170 Daltons to about 4000 Daltons; the tannin:peroxide weight ratio ranges from about 1:1000 to about 10:1; and, the composition at least inhibits a gastrointestinal spasm associated with gastroesophageal reflux disease in the subject when compared to a second subject in a control group in which the composition was not administered.

Methods of treating gastroesophageal reflux disease

Methods of treating a gastrointestinal spasms associated with chemotherapy or radiation therapy are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.

Methods of treating a gastrointestinal spasm associated with chemotherapy or radiation therapy

The teachings provided herein generally relate to site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites. More particularly, the systems taught here include a phenolic compound bound to a reactive oxygen species, wherein the phenolic compound and the reactive oxygen species react at a target area in the presence of an oxidoreductase enzyme.

Method of treating damaged mucosal or gastrointestinal tissue by administering a composition comprising a mixture of pomegranate and green tea extracts and releasably bound hydrogen peroxide

Methods of treating drug side-effects including gastrointestinal spasms are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.

Methods of treating drug side-effects that include a gastrointestinal spasm

Methods of treating necrotic enteritis are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.

Methods of treating necrotic enteritis

Methods of treating malnutrition are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.

Growing community of inventors

Menlo Park, CA, United States of America

Alexander L Huang