Integenx, Inc.

Illumina Corporation

Alexander Kindwall

David A King

Chungsoo Charles Park

Robert A Schueren

Dale Buermann

James Klevenberg

Stevan Bogdan Jovanovich

David G Nilson

Mattias Vangbo

Philip Justus Wunderle

Rick Pittaro

Tristan Robert Littlehale

Stanley S Hong

Mark T Reed

Mark R Pratt

Mark Wang

Drew R Verkade

Jason Bryant

Bryan Crane

Patrick Leung

Jason Harris

Frederick G Erie

Fedor Ilkov

Andrew James Carson

Eric Williamson

Fedor IIkov

David Grant Nilson

An electrophoresis cartridge can include an integrated electrophoresis assembly including an anode sub-assembly comprising an anode, a cathode sub-assembly comprising a cathode; and at least one electrophoresis capillary having a first end in fluid communication with the cathode sub-assembly and a second end in fluid communication with the anode sub-assembly. The cartridge can further include a reagent container comprising electrophoresis buffer; a fluid conduit in fluidic communication with the reagent container; a pump in fluidic communication with the fluid conduit, the pump configured to transfer the electrophoresis buffer through the fluid conduit from the reagent container to the passage of the cathode sub-assembly; and a sample inlet port and at least one sample line, wherein the sample line places the sample inlet port in fluidic communication with the first end of the electrophoresis capillary through a passage in the cathode sub-assembly.

Systems and methods for sample preparation, processing and analysis

The present disclosure provides systems and methods for sample preparation, processing and analysis. Also provided in the present disclosure is a fully-integrated electrophoresis cartridge which has a small footprint and configured to removably engage with the system.

Housing for biochemical analysis apparatus

A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.

Systems, methods, and apparatuses to image a sample for biological or chemical analysis

A method for controlling focus of an optical system. The method includes providing a pair of incident light beams to a conjugate lens. The incident light beams are directed by the lens to converge toward a focal region. The method also includes reflecting the incident light beams with an object positioned proximate to the focal region. The reflected light beams return to and propagate through the lens. The method also includes detecting a phase of each of the reflected light beams and determining a degree-of-focus of the optical system with respect to the object by comparing the phases of the reflected light beams.

Focusing methods and optical systems and assemblies using the same

A method for controlling a focus of an optical system. The method includes providing a pair of incident light beams to a conjugate lens. The incident light beams are directed by the lens to converge toward a focal region. The method also includes reflecting the incident light beams with an object positioned proximate to the focal region. The reflected light beams return to and propagate through the lens. The method also includes determining relative separation measured between the reflected light beams and determining a degree-of-focus of the optical system with respect to the sample based upon the relative separation.

Growing community of inventors

Pleasanton, CA, United States of America

Alexander Kindwall