University of Minnesota

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Arizona State University

Finch Therapeutics Holdings LLC

Alexander Khoruts

Michael J Sadowsky

Matthew J Hamilton

Alexa R Weingarden

Christopher M Staley

Thomas Julius Borody

James Adams

Rosa Krajmalnik-Brown

Dae-Wook Kang

The present invention provides compositions that include an extract of human feces, and methods for using such compositions, including methods for replacing or supplementing or modifying a subject's colon microbiota, and methods for treating a disease, pathological condition, and/or iatrogenic condition of the colon.

Compositions and methods for transplantation of colon microbiota

The present disclosure provides compositions and methods for treatinginfection (CDI) including primary and recurrent CDI. In particular, the compositions and methods described herein are capable of achieving a CDI clearance rate of at least 80% through a single oral dose of a pharmaceutical composition comprising a freeze-dried fecal microbiota preparation.

Compositions and methods fortreatment

The present disclosure provides compositions and methods for treatinginfection (CDI) including primary and recurrent CDI. In particular, the compositions and methods described herein are capable of achieving a CDI clearance rate of at least 80% through a single oral dose of pharmaceutical composition comprising a freeze-dried fecal microbiota preparation.

The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for ASD treatment in a subject in need thereof comprising or consisting essentially of administering a therapeutic composition comprising a fecal microbe or a fecal microbiota preparation to the subject. Also provided here is a method comprises administering an antibiotic to a human subject; subjecting the human subject to a bowel cleanse; and administering purified fecal microbiota to the human subject. Further provided are evaluation and quantitative characterization of patient symptom improvements upon treatment described here.

Methods for treating autism spectrum disorder and associated symptoms

Growing community of inventors

Golden Valley, MN, United States of America

Alexander Khoruts