Mayo Foundation for Medical Education and Research

University Health Network

Alexander Keith Stewart

William L Thomas

Robert J Greenhouse

Artem Plekhov

Nikolai Sepetov

Rafael Fonseca

Brian Rich

Esteban Braggio

Rodger E Tiedemann

Wen Yang

Aaron David Schimmer

Zhiwei Tong

Xinliang Mao

Peter Bergsagel

This document relates to inhibitors of G protein coupled receptor 6 kinase (GRK6) polypeptides as well as methods and materials for using such inhibitors to treat hematological malignancies, inflammation diseases, and autoimmune disorders.

Inhibiting G protein coupled receptor 6 kinase polypeptides

Small molecule inhibitors of G protein coupled receptor 6 kinases polypeptides

This document provides methods and materials related to assessing responsiveness to lenalidomide, thalidomide, and/or other IMiDs (structural and functional analogues of thalidomide that represent a promising new class of immunomodulators). For example, methods and materials for using CRBN levels to determine whether or not cancer cells (e.g., multiple myeloma cells) are susceptible to lenalidomide, thalidomide, and/or other IMiDs are provided.

Methods and materials for assessing responsiveness to lenalidomide, thalidomide, and/or other thalidomide analogs

This document involves methods and materials related to inhibiting cyclin D polypeptide activity. For example, this document provides methods and materials that can be used to (1) identify mammals or cells in need of cyclin D polypeptide inhibition and (2) administer an agent capable of inhibiting cyclin D polypeptide activity.

Inhibiting cyclin D polypeptides

Growing community of inventors

Scottsdale, AZ, United States of America

Alexander Keith Stewart