Varian Medical Systems, Inc.

Siemens Healthineers International Ag

Varian Medical Systems International Ag

Varian Medical Systems Particle Therapy Gmbh & Co Kg

Varian Medical Systems Particle Therapy Gmbh

Alexander Katsis

Eric Abel

Timo K Koponen

Christel Smith

Anthony Magliari

Perttu Niemela

Michael Matthew Folkerts

Renate Parry

Reynald Vanderstraeten

Jessica Perez

Rajiv Dua

Matti Ropo

Michiko Alcanzare

A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. A quantitative time-dependent model-based charged particle pencil beam scanning optimization is then implemented for FLASH therapy.

Model based PBS optimization for flash therapy treatment planning and oncology information system

Information that describes a target inside a patient to be treated with radiation is accessed from computer system memory. An arrangement of spots inside the target is determined. Each the spots corresponds to a location inside the target where a respective beam of radiation is to be directed during radiation treatment of the patient. A dose rate for each of the beams is determined. The dose rate for each beam is a dose delivered in less than one second to a spot corresponding to that beam. For example, each beam can deliver at least four grays (GY) in less than one second, and may deliver as much as 20 Gy to 50 Gy or 100 Gy or more in less than one second. A radiation treatment plan, that includes the arrangement of the spots and the dose rate for each of the beams, is stored in computer system memory.

Radiation treatment planning for delivering high dose rates to spots in a target

Embodiments of the present invention provide an integrated solution to radiotherapy treatment planning that enables accurate recording and accumulation of physical parameters as input (e.g., dose, dose rate, irradiation time per voxel, etc.). User-defined functions are evaluated to correlate the input parameters with 4D biological outcomes. The resulting biological parameters can be visualized as a biological outcome map to evaluate decisions, support decisions, and optimize decisions regarding the parameters of the radiotherapy treatment plan, for example, for supporting clinical trials and related clinical research.

System and method for biological treatment planning and decision support

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San Mateo, CA, United States of America

Alexander Katsis