Elfi-tech Ltd.

Oxitone Medical Ltd.

Alexander Kaminsky

Ilya Fine

Leon Eisen

A method and apparatus for hemodynamically characterizing a neurological or fitness state by dynamic scattering light (DLS) is disclosed herein. In particular, a non-pulsatile blood-shear-rate-descriptive (BSRD) signal(s) is optically generated and analyzed. In some embodiments, the BSRD signal is generated dynamically so as to adaptively maximize (i.e. according to a bandpass or frequency-selection profile) a prominence of a predetermined non-pulsatile physiological signal within the BSRD. In some embodiments, the BSRD is subjected to a stochastic or stationary-status analysis. Alternatively or additionally, the neurological or fitness state may be computed from multiple BSRDs, including two or more of: (i) a [sub &#x2212;200 Hz, &#x2dc;300 Hz] BSRD signal; (ii) a [&#x2dc;300 Hz, &#x2dc;1000 Hz] signal; (iii) a [&#x2dc;1000 Hz, &#x2dc;4000 Hz] signal and (iv) a [&#x2dc;4000 Hz, z Hz] (z&#x3e;=7,000) signal.

Method and apparatus for hemodynamically characterizing a neurological or fitness state by dynamic light scattering (DLS)

Methods and systems of optically measuring systolic and/or diastolic blood pressure of a mammal having biological tissue are disclosed herein. In some embodiments, the system comprises an optical blood motion sensor, a gas-sealable inflatable cushion having a flexible and transparent (FOT) barrier section, and an optical blood motion sensor comprising a laser. When pressure (e.g. at least systolic pressure) illuminates the tissue, laser light may pass en route to the tissue through the FOT sealing barrier section of the gas-sealable inflatable cushion as well as cushion interior. In some embodiments, a rigid restrictor comprising an optically transparent section is provided, and laser light also passes through the optically transparent section of the rigid restrictor en route to the biological tissue.

Method and apparatus for optically measuring blood pressure

A method and apparatus for hemodynamically characterizing a neurological or fitness state by dynamic scattering light (DLS) is disclosed herein. In particular, a non-pulsatile blood-shear-rate-descriptive (BSRD) signal(s) is optically generated and analyzed. In some embodiments, the BSRD signal is generated dynamically so as to adaptively maximize (i.e. according to a bandpass or frequency-selection profile) a prominence of a predetermined non-pulsatile physiological signal within the BSRD. In some embodiments, the BSRD is subjected to a stochastic or stationary-status analysis. Alternatively or additionally, the neurological or fitness state may be computed from multiple BSRDs, including two or more of: (i) a [sub-200 Hz, &#x2dc;300 Hz] BSRD signal; (ii) a [&#x2dc;300 Hz, &#x2dc;1000 Hz] signal; (iii) a [&#x2dc;1000 Hz, &#x2dc;4000 Hz] signal and (iv) a [&#x2dc;4000 Hz, z Hz] (z&#x3e;=7,000) signal.

Embodiments of the invention relate to a method and apparatus for measuring at least one parameter that is (i) descriptive of stochastic motion of suspended particles within a fluid; and/or (ii) is a rheological property of the fluid or of the suspension; (iii) describes a concentration of suspended particles within the fluid; and/or (iv) is a diffusion coefficient of the suspended particles and/or (iv) is a viscosity of the fluid or of the suspension; and/or (v) is a food aging or spoilage parameter and/or (vii) is an in-vivo or in-vitro blood coagulation parameter.

Ensemble-averaged measurement of stochastic motion by current-modulating of VCSEL wavelength

A system and method for measuring one or more light-absorption related blood analyte concentration parameters of a mammalian subject, is disclosed. In some embodiments, the system comprises: a) a photoplethysmography (PPG) device configured to effect a PPG measurement by illuminating skin of the subject with at least two distinct wavelengths of light and determining relative absorbance at each of the wavelengths; b) a dynamic light scattering measurement (DLS) device configured to effect a DLS measurement of the subject to rheologically measure a pulse parameter of the subject; and c) electronic circuitry configured to: i) temporally correlating the results of the PPG and DLS measurements; and ii) accordance with the temporal correlation between the PPG and DLS measurements, assessing value(s) of the one or more light-absorption related blood analyte concentration parameter(s).

Photoplethysmography device and method

Embodiments of the present invention relate to a system and method for in vivo measurement of blood parameters by processing analog electrical signals from a plurality of photodetectors. In some embodiments, it is possible to determine one or more blood parameters according to (i) a first electrical signal from a first detector and (ii) a second electrical signal from a second photodetector. A difference analog electrical signal is generated, indicative of a difference between the light response signal at the first location and light response signal at the second location, is generated. One or more blood parameters may be detected according to the difference analog electrical signal.

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Rehovot, Israel

Alexander Kaminsky