Polares Medical Inc.

Cardiokinetix, Inc.

Pacesetter, Inc.

Atritech, Inc.

Middle Peak Medical, Inc.

Usgi Medical, Inc.

Eclipse Surgical Technologies, Inc.

Other

Edwards Lifesciences Corporation

Bacchus Vascular Inc.

Ev3 Endovascular, Inc.

Ev3 Sunnyvale, Inc.

Covidien LP

Vquad Medical LLC

Tyco Healthcare Group LP

Alexander K Khairkhahan

Alan Klenk

Michael D Lesh

Serjan D Nikolic

Erik Van Der Burg

Chad C Roue

Andrew G C Frazier

Marc S Kreidler

Hugh R Sharkey

Stewart M Kume

Darrell H Ogi

Thomas Blake Eby

Dino De Cicco

Zaya Tun

Michael A Evans

Kelvin Ning

Brett Andrew Snyder

Tyler Jon Strang

Vahid Saadat

Denise M Demarais

Michael J Horzewski

Anuja H Patel

Branislav Radovancevic

Michael J Rosinko

Richard L Mueller

Cang C Lam

Janine C Robinson

James Raymond Kermode

Robert G Quintos

Dino DeCicco

Richard Christian Ewers

Craig E Mar

Paul M Paspa

Michael P Boutillette

Douglas R Murphy-Chutorian

Eric J Varady

Stuart D Harman

Miles D Alexander

Tracy D Maahs

Sebastian Khairkhahan

Rich C Ewers

Jacques Essinger

Danielle Tene

Jennifer Jandak

Alan R Klenk

Denise Marie Zarins

Stephen Arie Leeflang

Alan H Ostroff

Ruey-Feng Peh

Kenneth J Michlitsch

Kenneth J Carroll

Jesus Flores

Jody Maria Cimbalo

Roberto De Filippo

Denise Demarias

Craig Mar

The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance devices for implantation across the valve; a system including the coaptation enhancement element and anchors for implantation; a system including the coaptation enhancement element, and one or more of the following: transseptal sheath, anchor delivery catheter, implant delivery catheter, and clip delivery catheter; and methods for transcatheter implantation of a coaptation element across a heart valve.

Systems and methods for transcatheter treatment of valve regurgitation

The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance element for implantation across the valve; a system including the coaptation assistance element and anchors for implantation; a system including the coaptation assistance element and delivery catheter; and a method for transcatheter implantation of a coaptation element across a heart valve.

Device, system, and method for transcatheter treatment of valvular regurgitation

A catheter system for retrieving a leadless cardiac pacemaker from a patient is provided. The cardiac pacemaker can include a docking or retrieval feature configured to be grasped by the catheter system. In some embodiments, the retrieval catheter can include a snare configured to engage the retrieval feature of the pacemaker. The retrieval catheter can include a torque shaft selectively connectable to a docking cap and be configured to apply rotational torque to a pacemaker to be retrieved. Methods of delivering the leadless cardiac pacemaker with the delivery system are also provided.

Pacemaker retrieval systems and methods

The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation enhancement element for implantation across the valve; a system including the coaptation enhancement element and anchors for implantation; a system including the coaptation enhancement element, catheter and driver; and a method for transcatheter implantation of a coaptation element across a heart valve.

Device, system, and method for transcatheter treatment of valve regurgitation

A suture clip includes a disc body having at least two adjacent portions joined by a hinge at one end and a latch at another end. Suture engagement surfaces are formed on a first and second portion of the disc body so that the first and second suture engagement surfaces can close sufficiently tightly to immobilize a pair of suture lengths therebetween when the two portions are closed and held together by the latch. A suture clip applier holds a plurality of such suture clips typically in a magazine, an open configuration where the suture engagement surfaces are held apart. Single suture clips are advanced by an advancement mechanism over a pair of suture ends having a midsection in tissue. A closing mechanism closes and latches the first and second portions of the disc body together to capture the pair of suture ends therebetween.

Suture clip and suture clip applier

Implants, implant systems, and methods for treatment of mitral valve regurgitation and other valve diseases generally include a coaptation assist body which remains within the blood flow path as the leaflets of the valve move, the valve bodies often being relatively thin, elongate (along the blood flow path), and/or conformable structures which extend laterally from commissure to commissure, allowing the native leaflets to engage and seal against the large, opposed surfaces on either side of the valve body during the heart cycle phase when the ventricle contracts to empty that chamber of blood, and allows blood to pass around the valve body so that blood flows from the atrium to the ventricle during the filling phase of the heart cycle. Separate deployment of independent anchors near each of the commissures may facilitate positioning and support of an exemplary triangular valve body, with a third anchor being deployed in the ventricle. An outer surface of the valve body may accommodate tissue ingrowth or endothelialization, while a fluid-absorbing matrix can swell after introduction into the heart. The valve body shape may be selected after an anchor has been deployed, and catheter-based deployment systems may have a desirable low profile.

Coaptation enhancement implant, system, and method

The invention relates in some aspects to a device for use in the transcatheter treatment of mitral valve regurgitation, including steerable guidewires, implantable coaptation assistance devices, anchoring systems for attaching a ventricular projection of an implantable coaptation device, a kit, and methods of using an implantable coaptation assistance device among other methods.

Mitral valve implants for the treatment of valvular regurgitation

Devices are disclosed for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance element for implantation across the mitral valve and an edge to edge device. Methods are disclose for reducing mitral valve regurgitation at low left ventricle pressure and high left ventricle pressure during the cardiac cycle. Devices are disclosed for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance element for implantation across the mitral valve with an adaptive coaptation element.

Growing community of inventors

Palo Alto, CA, United States of America

Alexander K Khairkhahan