Massachusetts Institute of Technology

Colgate Palmolive Company

Alexander James Mijalis

Klavs F Jensen

Bradley Lether Pentelute

Mark David Simon

Dale Arlington Thomas, Iii

Surin Mong

Evangelia Arvanitidou

Gregory Szewczyk

Jason Nesta

Andrea Adamo

Patrick Louis Heider

Dale Arlington Iii Thomas

Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system. In some embodiments, the methods and systems, described herein, can be used to conduct quality control to determine and correct problems (e.g., aggregation, truncation, deletion) in reactions (e.g., coupling reactions) taking place in the solid phase peptide synthesis system.

Methods and systems for solid phase peptide synthesis

Provided is an oral care composition comprising a phosphate/acrylate co-polymer, a whitening agent and an orally acceptable carrier and methods of using the same.

Oral care compositions and methods

Growing community of inventors

Shreveport, LA, United States of America

Alexander James Mijalis