Sartorius Stedim Biotech Gmbh

Alexander Helling

Martin Leuthold

Ulrich Grummert

Ceren Gencoglu

A bioreactor having a filter unit and a method for treating a cell broth. The filter unit has a supply channel (), a first filter medium (), a retentate channel (), a second filter medium () and a permeate channel (), arranged so that the first filter medium delimits the supply channel and the retentate channel from one another; and the second filter medium delimits the retentate channel and the permeate channel from one another. The supply channel is connected to an inlet for a supply medium; the retentate channel is connected to an inlet for a cell broth and to an outlet for the cell broth; the permeate channel is connected to an outlet for a permeate; and the interior of the bioreactor is connected to the inlet for the cell broth and to the outlet for the cell broth.

Bioreactor with filter unit and method for treating a cell broth

A method for degassing a cross-flow diafiltration unit, a cross-flow diafiltration method and a cross-flow diafiltration unit. The degassing method includes (i) providing a cross-flow diafiltration unit having a diafiltration channel, a retentate channel and a permeate channel, a first filter material that delimits the diafiltration channel from the retentate channel, and a second filter material that delimits the retentate channel from the permeate channel; and thereafter (ii) feeding a liquid into the retentate channel so that the liquid flows in a flow direction through the retentate channel and penetrates through the first filter material into the diafiltration channel, whereby the retentate channel and the diafiltration channel are filled with and degassed by the liquid.

Method for degassing a cross-flow diafiltration unit, cross-flow diafiltration method and cross-flow diafiltration unit

A device and a method for repeatedly modifying the composition of a fluid. The device includes a first module () modifying the composition of the fluid, a second module () modifying the composition of the fluid and a dwell module () with an inlet () and an outlet (). The first module is connected in a fluid-conducting manner to the dwell module inlet and the dwell module outlet is connected in a fluid-conducting manner to the second module. Either the first or the second module is a filter unit, or the first module is a first filter unit and the second module is a second filter unit. The filter unit(s) include(s) at least one first filter medium () delimiting a supply channel () and a retentate channel () and at least one second filter medium () delimiting the retentate channel and a permeate channel ().

Growing community of inventors

Ebergoetzen, Germany

Alexander Helling