Smithkline Beecham Corporation

Other

Alexander H Taylor

Zdenka Ludmila Jonak

Kyung Oh Johanson

Stephen Dudley Holmes

Stephen H Trulli

Peter R Young

Connie L Erickson-Miller

Sherin Salaheldin Abdel-Meguid

Yen Sen Ho

Han N Trinh

Stephen D Holmes

This invention relates to novel humanized and other recombinant or engineered antibodies or monoclonal antibodies to the vitronectin &#x3b1;&#x3b2;receptor and to the genes encoding same. Such antibodies are useful for the therapeutic and/or prophylactic treatment of &#x3b1;&#x3b2;-mediated disorders, such as restenosis, in human patients.

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Anti-alphabeta3 humanized monoclonal antibodies

This invention relates to novel humanized and other recombinant or engineered antibodies or monoclonal antibodies to a human &#x3b1;subunit-containing heterodimeric integrin receptors and to the genes encoding same. Such antibodies are useful for the therapeutic and/or prophylactic treatment of disorders mediated by such receptors, such as cancer, in human patients.

Nucleic acids encoding anti-human &#x3b1;&#x3bd;&#x3b2;3 and &#x3b1;&#x3bd;&#x3b2;5 antibodies

Erythropoietin receptor agonist and antagonist antibodies and their use in enhancing erythropoiesis are disclosed.

Erythropoietin receptor antibodies

Antibodies having reduced immunogenicity and methods for making them are disclosed.

Monoclonal antibodies with reduced immunogenicity

Chimeric, humanized and other IL-18 mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.

Monoclonal antibody and the method of using the antibody

Macaca cynomolgus IL18 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize Macaca cynomolgus IL18. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: cancer and auto-immune diseases.

Macaca cynomolgus IL 18

This invention relates to novel humanized and other recombinant or engineered antibodies or monoclonal antibodies to a human .alpha..sub.v subunit-containing heterodimeric integrin receptors and to the genes encoding same. Such antibodies are useful for the therapeutic and/or prophylactic treatment of disorders mediated by such receptors, such as cancer, in human patients.

Growing community of inventors

Exton, PA, United States of America

Alexander H Taylor