Edwards Lifesciences Corporation

Edwards Lifesciences Cardiaq LLC

Nikon Corporation

Nikon Metrology Nv

Inqb8 Medical Technologies, LLC

Alexander H Cooper

Glen Thomas Rabito

David Robert Landon

Matthew A Peterson

J Brent Ratz

Julio Cesar Sanchez

David Mark Taylor

Arshad Quadri

Kevin M Stewart

Garrett Dallas Johnson

Asher L Metchik

Travis Zenyo Oba

Lauren R Freschauf

Daniel Gene Smith

Eric Peter Goodwin

Siddharth Vad

William Charles Brunnett

Seung-Beom Yi

Lindsay Lam

Patrick Chow

Sergio Delgado

Mark Chau

Tri D Tran

Luca Pesce

Darshin S Patel

Sean Chow

Anthony R Slotwinski

Hieu Minh Luong

Kevin M Golemo

Mina A Rezk

Yuanlong Du

Thomas M Hedges

Eric Robert Dixon

Alexander J Siegel

Matthew T Winston

Yaron Keidar

Emil Karapetian

Gregory Scott Tyler, Ii

David Leigh Hauser

Gregory I Bak-Boychuk

Christopher J Olson

Michael R Bialas

Cristobal R Hernandez

Bao Khuu

Michael J Popp

Alec Paul Robertson

Amanda French

Tarannum Ishaq Gutierrez

Yen Liao

Pui Tong Ho

Taylor Jacob Scheinblum

Zachary R Kowalski

Art Z Kwan

Jesse Robert Edwards

Ramon Aguilar, Jr

Amanda Kristine Anderson White

Hiroshi Okabe

Brian L Stamper

Juliet Laura Schwartz

Brent J Ratz

Glen T Rabito

Stanton J Rowe

Douglas C Watson

Alton Hugh Phillips

David Michael Williamson

Robert C Taft

Tram Ngoc Nguyen

Scott Coakley

Evan T Schwartz

Michel Pharand

Jocelyn Chau

Amanda K Anderson

Kurt Kelly Reed

Victoria Cheng-Tan Wu

Alyssa Joy Gross

Jason Seng-Che Lam

Lisong Ai

Ngoc Huong Thi Nguyen

Corey Maurice Marshall

Wendy Vo Pham

Hannah Reed Bettencourt

Ramon Aguilar

Gregory Scott Ii Tyler

Systems, assemblies, and methods for treating valve regurgitation and other valve problems are described. Prosthetic valves can have integrated coverings or flanges. Prosthetic valves can have a flange attached to the inflow end of the annular frame and designed to extend outwardly therefrom. Docking devices can be used to repair or reshape native heart valves and to secure prosthetic heart valves at a specific location and position relative to a native heart valve. Delivery systems can be used to deploy a docking device into the heart, including a lubricous sleeve in the delivery system. Packaging and storage systems suitable for the delivery systems are described.

Systems, devices, and methods for treating heart valves

A prosthesis can be configured to grasp intralumenal tissue when deployed within a body cavity and prevent axial flow of fluid around an exterior of the prosthesis. The prosthesis can include an expandable frame configured to radially expand and contract for deployment within the body cavity and a valve body. The expandable frame can include a frame body and a supplemental frame. The valve body can include a plurality of leaflets and one or more intermediate components. The one or more intermediate components can couple at least a portion of the leaflets to the expandable frame. The prosthesis can include an annular flap positioned around an exterior of the expandable frame.

Replacement heart valve prosthesis

A method of implanting a prosthetic heart valve at a native tricuspid valve region includes delivering a prosthetic heart valve to the native tricuspid valve region via the inferior vena cava or the superior vena cava and deploying the prosthetic heart valve from a sheath of a delivery apparatus. The prosthetic heart valve includes a radially compressible and expandable frame assembly having an inflow end, an outflow end, and a double-body structure having an annular inner frame and an annular outer frame. The outer frame preferably includes an atrial flange portion configured to contact an atrial face of the native tricuspid valve region. The prosthetic heart valve can further include a plurality of ventricular anchors, each comprising a free end portion and a fixed end portion connected to and extending from the frame assembly at a location spaced from the outflow end of the frame assembly.

Method for replacing a tricuspid valve

Certain aspects of the disclosure concern a device for repairing or replacing a native heart valve. The device can include a frame including a first set of struts intersecting with a second set of struts at a plurality of strut connection points. The frame can be radially expandable from a radially collapsed state to a radially expanded state. The device can include at least one expansion feature including a screw head and a screw shaft connected to the screw head. The screw shaft can extend through a first strut connection point and a second strut connection point. The device can further include a plurality of penetrating members extending from a first end of the frame. Rotating the screw shaft in a first direction can radially expand the frame from the radially collapsed state to the radially expanded state.

Cardiac valve repair devices configured for percutaneous delivery

Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. A delivery component can have a plurality of slots that provide for desired bending of the delivery component, particularly compound bending of the delivery component that can facilitate steering of the delivery component in three dimensions.

Steerable delivery system for replacement mitral valve and methods of use

In a particular embodiment, the present disclosure provides a prosthetic valve delivery assembly that includes a storage tube and a nose cone cap. A prosthetic valve having a frame is at least partially disposed within the storage tube. A nose cone is disposed about an elongated shaft. The nose cone cap and the storage tube have mating first and second locking member that can be coupled to selectively secure the nose cone cap to the storage tube.

Storage assembly for prosthetic valve

Devices, systems and methods are described for implantation of a prosthesis within a lumen or body cavity and delivery systems for delivering the prosthesis to a location for implantation. A delivery system can include a tether connected to a single directional handle knob for release of the prosthesis within the lumen or body cavity and retraction of the tether towards the handle.

Delivery device and methods of use for transapical delivery of replacement valve

In one representative embodiment, an implantable prosthetic device comprises a spacer body portion configured to be disposed between native leaflets of a heart, and an anchor portion configured to secure the native leaflets against the spacer body portion. The prosthetic device can be movable between multiple configurations. The spacer body can be configured to extend radially outwardly as the spacer body extends away from the distal end toward the proximal end. A delivery apparatus can have a first shaft and a second shaft, wherein movement of the first shaft relative to the second shaft moves the anchor portion relative to the spacer body.

Heart valve sealing devices and delivery devices therefor

Various systems, devices, components and methods are disclosed for controllably and selectively occluding, restricting, and/or diverting flow within a patient's vasculature. The flow restriction systems can include an implant having a flow restrictor and an implantable controller having an actuator for actuating the flow restrictor. The flow restriction systems can also include an external device for controlling operation of the implant via the implantable controller.

Systems, devices, and methods for controllably and selectively occluding, restricting, and diverting flow within a patient's vasculature

Devices, systems and methods are described herein to provide improved steerability for delivering a prosthesis to a body location, for example, for delivering a replacement mitral valve to a native mitral valve location. The steerable delivery system can contain a steerable rail configured for multi-plane bending to direct a distal end of the delivery system.

Steerable rail delivery system

A method of replacing the function of a native heart valve is achieved by inserting a distal end portion of a delivery apparatus into a patient's body, wherein a prosthetic valve is disposed along the distal end portion of the delivery apparatus. The prosthetic valve includes a collapsible and expandable annular body having a network of struts interconnected at a plurality of nodes to form a plurality of open cells. Atrial and ventricular flanges are coupled to the annular body and extend radially away from the annular body. The annular body includes three commissure support posts of fixed length that extend substantially the entire length of the annular body. A valve member is secured to the commissure support posts. The annular body is radially expanded within the native heart valve and the atrial and ventricular flanges are deployed on opposite sides of the native heart valve.

Dual-flange prosthetic valve frame

In one representative embodiment, an implantable prosthetic device comprises a spacer body portion configured to be disposed between native leaflets of a heart, and an anchor portion configured to secure the native leaflets against the spacer body portion. The prosthetic device can be movable between multiple configurations. The spacer body can be made from braided, self-expandable metallic thread. A delivery apparatus can have a first shaft and a second shaft, wherein movement of the first shaft relative to the second shaft moves the anchor portion relative to the spacer body.

Embodiments of a prosthetic heart valve comprise an annular main body, an atrial cap extending radially outwardly from the atrial end of the main body, and a plurality of ventricular anchors extending outwardly from the ventricular end of the main body. Each ventricular anchor can have a proximal end portion connected to the ventricular end, an intermediate portion extending away from the atrial end and then back toward the atrial so as to define a first bend, and a free distal end portion that extends from the intermediate portion. The distal end portion can comprise a first section, a second section, and a second bend between the first and second sections, the first section extending from the intermediate portion in a direction toward the atrial end and radially away from the main body.

Prosthetic valve for replacing a native mitral or tricuspid valve

A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

Multi-portion replacement heart valve prosthesis

Growing community of inventors

Costa Mesa, CA, United States of America

Alexander H Cooper