Ortho-clinical Diagnostics, Inc

Agilent Technologies, Inc.

Grifols Worldwide Operations Limited

Alexander Gyenes

David Y Chien

Angelica Medina-Selby

Doris Guenzi Coit

Jian Zheng

John Andrew Hall

Michael J Kimzey

Toshiya Fujihara

The invention relates to an activated form of procaine, and the use of the activated procaine, or salts or solvates thereof, to label amine-containing compounds, such as N-glycans, amine-containing amino acids, amine-containing peptides, amine-containing proteins, or other amine-containing compounds in a sample. Use of activated procaine as a label allows for sensitive detection of compounds labeled with it by both fluorescence and mass spectrometry.

Methods for labeling amine-containing compounds

The invention relates to an activated form of procaine, and the use of the activated procaine, or salts or solvates thereof, to label amine-containing compounds, such as N-glycans, amine-containing amino acids, amine-containing peptides, amine-containing proteins, or other amine-containing compounds in a sample. Use of activated procaine as a label allows for sensitive detection of compounds labeled with it both by fluorescence and by mass spectrometry.

Compound for labeling amine-containing compounds, and its use

Modified hepatitis C virus polypeptides are described. The polypeptides include the HCV NS4a domain and modified NS3 domain. The polypeptides retain conformational epitopes. HCV immunoassays including the polypeptides are also described.

HCV NS4a/modified NS3 polypeptides and uses thereof

HCV NS4A/modified NS3 polypeptides and uses thereof

Growing community of inventors

San Francisco, CA, United States of America

Alexander Gyenes