Johnson and Johnson Vision Care, Inc.

Alexander Guzman

Azaam Alli

Donald E Riederer

Bernardo Santa Maria

Ghulam Maharvi

Yong Zhang

Jaqunda Patton

Shivkumar Mahadevan

Michael Francis Widman

Xin Wei

Minghan Chen

Described is a silicone hydrogel contact lens having non-uniform morphology. The contact lens may be made from a reactive mixture comprising: a silicone-containing component; a hydrophilic component; a non-reactive polymeric internal wetting agent; and a polymerization initiator, the contact lens having an oxygen permeability of at least about 60 barrers, and wherein the molar ratio in the lens of the polymeric non-reactive internal wetting agent to silicone, without a surface treatment, is greater in the lens's surface than in its bulk.

Silicone hydrogel contact lenses having non-uniform morphology

Provided are compounds that may function as functionalized polymerization initiators, for instance in the manufacture of ophthalmic lenses, and to methods of such manufacture. The compounds are of formula I: wherein R, R, R, R, R, T, p, q, and n are as defined herein.

Amide-functionalized polymerization initiators and their use in the manufacture of ophthalmic lenses

Provided are ink compositions for making cosmetic contact lenses, as well as cosmetic contact lenses and methods for their preparation and use. The ink composition comprises: (a) a colorant; and (b) a nonreactive hydrophilic polymer.

Ink composition for cosmetic contact lenses

Described are silicone hydrogels that are more biocompatible than current ocular materials. The silicone hydrogels are formed from a reactive monomer mixture comprising: a mixture of hydroxyl substituted silicone containing components, at least one polyamide; and at least one hydrophilic monomer. The silicone hydrogels also display a desirable balance of properties, including clarity, oxygen permeability, wettability and desirable protein uptake.

Silicone hydrogels comprising polyamides

Provided are ink compositions for making cosmetic contact lenses, as well as cosmetic contact lenses and methods for their preparation and use. The ink composition comprises: (a) a colorant; (b) a hydrophilic polymer; and (c) a binder polymer comprising a triblock polymer of formula: [A]-[B]-[C], wherein [A], [B] and [C] are as described herein.

Described are silicone hydrogels with high levels of polyamides exhibiting an excellent balance of physical, mechanical, and biological properties. The silicone hydrogels are formed from a reactive monomer mixture comprising: a hydroxylalkyl (meth)acrylate monomer; hydroxyl-containing silicone components; and a polyamide, wherein the polyamide is present in an amount greater than 15 weight percent, based on the total weight of reactive components in the reactive monomer mixture.

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Jacksonville, FL, United States of America

Alexander Guzman