Quantum-si Incorporated

Alexander Goryaynov

Jonathan Marc Rothberg

Jeremy Lackey

Keith Glen Fife

Todd Rearick

Gerard M Schmid

Ali Kabiri

Jonathan C Schultz

Farshid Ghasemi

Guojun Chen

Benjamin Cipriany

Brian Reed

James A Ball

Faisal R Ahmad

Xinghua Shi

Thomas Christian

Michael Bellos

Systems and methods are described for producing an amplitude-modulated laser pulse train. The laser pulse train can be used to cause fluorescence in materials at which the pulse trains are directed. The parameters of the laser pulse train are selected to increase fluorescence relative to a constant-amplitude laser pulse train. The amplitude-modulated laser pulse trains produced using the teachings of this invention can be used to enable detection of specific molecules in applications such as gene or protein sequencing.

Amplitude-modulated laser

Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned adjacent to the reaction chamber that produce one or more electric fields that assist loading the sample into the reaction chamber. The apparatus may further include a sample reservoir having a fluid seal with the surface of the integrated device and configured to hold a suspension containing the samples.

System and methods for electrokinetic loading of sub-micron-scale reaction chambers

Methods of loading a molecule of interest into a sample well are provided. In some aspects, methods of loading a molecule of interest into a sample well involve loading a molecule of interest into a sample well in the presence of a crowding agent and/or a condensing agent. In some aspects, methods of loading a sequencing template into a sample well are provided.

Loading molecules into sample wells for analysis

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New Haven, CT, United States of America

Alexander Goryaynov