Becton Dickinson and Company Limited

Angiomed Gmbh & Co. Medizintechnik Kg

Alexander George Lastovich

Frank E Martin

Ronald J Pettis

M Ishaq Haider

James L Schram

John A Mikszta

Jason B Alarcon

James Fentress

John P Dekker, Iii

James A Down

Charles D Shermer

Noel G Harvey

Weston F Harding

Chad C Smutney

P Spencer Kinsey

John M Polidoro

Carl R Sahi

David S Chapin

Kenneth G Powell

Robert E Pearson

Christian Sandmann

Daniel M Stipe

Steven Keith

Adam C Curry

Matthew Daniel Solomon

Kristin Weidemaier

Helen V Hsieh

Andrea Liebmann-Vinson

Qihua Xu

Rajendra R Bhat

Ralph Lee Sonderegger

Glade Harold Howell

Lionel Vedrine

Timothy J Erskine

Edward Paul Browka

Michael A Brasch

Richard L Moore

Lawrence A Monahan

Richard P Clarke

Joshua Herr

Chris N Cindrich

Eric Fallows

Ross Jacobson

David S Sebba

Jon E Salomon

Jason Paul Hayes

John D Evans

Cristian Clavijo

Scott A O'Connor

Julia E Griggs

Jeff M Moss

W William Stewart

Anita Quinn

Pauline Elizabeth Bell

Rex Young Nielson

Lincoln Belcourt

Ed Browka

Diane Sutter

W Shannon Dillmore

Pia U Braeuer

Spencer P Kinsey

Matthew James Springer

Melody Kuroda

Jacob Jones

Sebastian Zickwolf

William Shannon Dillmore

Richard Abbott

Friedrich G Hahn

Shirley Ng

William Kevin Carpenter

Adam Craig Curry

Pia Ute Braeuer

James K Fentress

Sean Patrick Dowling

Jeff Moss

Diane E Sutter

Alexander Adam Papp

Richard Abbot

Sean Connell

Michael L Kiplinger

Caitlin Marie Austin

Henry Li-Wei Fu

Owen Lewis Joyce

Meghan Wolfgang

James Lee Schram

Jim Fentress

John P Iii Dekker

Kirstin Weidemaier

Ishaq M Haider

The present invention relates to a TIPS stent graft, comprising a tubular component having a lumen extending therethrough, the tubular component comprising a balloon expandable central section and a first and a second self-expanding section, the first and the second self-expanding section sandwiching the central section, the lumen extending through the first, central, and second sections, the stent graft being capable of selectively constricting the central section.

Tips stent graft and kit

A filtration cell () for a biological sample including an upper chamber for receiving the biological sample to be filtered, a lower chamber in fluid communication with the upper chamber, and a filtration membrane () positioned between the upper chamber and the lower chamber is disclosed. A surface of the filtration membrane has a contact angle &#x3e;90&#xb0;. The flow of the biological sample through the upper chamber may be tangential to the filtration membrane and a filtrate passing through the filtration membrane may be collected in the lower chamber. Also, a method of filtering a biological sample including passing the biological sample through an upper chamber of a filtration cell as described above and collecting a filtrate in the lower chamber is disclosed.

Filtration cell and method for filtering a biological sample

An assembly for preparing a specimen is provided that may be configured to determine the presence of at least one microorganism specie in the specimen. The assembly may include a pipette configured to acquire a specimen from a sample and an imaging cartridge configured to be in fluid communication with the pipette. The imaging cartridge and the pipette may be configured to be irreversibly coupled such that the specimen is bio-contained within the imaging cartridge and the pipette when the imaging cartridge and pipette are coupled together. Associated methods of use are also provided.

Imaging cartridge, pipette, and method of use for direct sputum smear microscopy

Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.

Assays using surface-enhanced raman spectroscopy (SERS)-active particles

Tissue dissociators configured to disrupt a biological tissue sample are provided. Aspects of the tissue dissociators according to certain embodiments include a blade holder having a blade and a sample holder that includes a tissue actuator having a distal end pliable stopper where the tissue actuator is configured to be displaced along a longitudinal axis with the sample holder. Also provided are methods of dissociating a biological tissue sample with the tissue dissociators, as well as kits including the tissue dissociators.

Devices for dissociating a biological tissue sample and methods of use thereof

A filtration cell () for a biological sample having an outer housing () defining a first chamber and an inner housing () defining a second chamber is disclosed. The inner housing is disposed within the first chamber and rotatable with respect to the outer housing and at least a portion of the inner housing includes a filtration membrane (). Upon rotation of the inner housing, a first portion of the biological sample passes from the first chamber into the second chamber and a second portion of the biological sample is restrained in the first chamber. Alternatively, the filtration cell may also include a rotation element disposed in the inner housing. Upon rotation of the rotation element with respect to the inner housing, a first portion of the biological sample to passes from the second chamber into the first chamber and a second portion of the biological sample is restrained in the second chamber.

Plasma extractor

A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.

Device for withdrawing or administering a substance and method of manufacturing a device

A system and method for a patch-like, self-contained substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir, wherein the device can be attached to a skin surface via an adhesive contact surface and a push button activation assembly can then be used to remove an interlock, allowing a disk, or Belleville spring assembly to apply an essentially even and constant pressure to the contents of the fluid reservoir, allow the release of the patient needles into the skin surface, and establish a fluid communication path between the patient needles and the pressurized fluid reservoir contents. The push button activation assembly further allows the release of one or more improved safety mechanisms after use.

Patch-like infusion device

An optical connector device is disclosed for optically connecting a biosensor wearable on the body of a patient to a reader outside of the body of the patient. The device comprises a base disk to be worn on the body of a patient. The base disk has a needle attached thereto and the needle houses a first fiber defining a first optical conduit. The distal end of the needle is insertable into the body of the patient, and a portion of the proximal end of the needle remains outside of the body of the patient when the device is worn. The device also comprises a connector housing a second fiber defining a second optical conduit.

Optical fiber connector

Device for withdrawing or administrating a substance and method of a device

Improved microprotrusion abrasion devices having fluid retaining or directing patterns, and specific design parameters and method for delivery of substances into the skin. Various configurations of such devices are disclosed, including domed, channeled, patterned and stepped.

Microprotrusion arrays and methods for using same to deliver substances into tissue

A system and method for a patch-like, self-contained substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir subassembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. Simple removal of an interlock allows a disk, or Belleville spring assembly to apply an essentially even and constant pressure to the contents of the fluid reservoir assembly, and allows the device to then be attached to a skin surface via an adhesive contact surface. A push button activation assembly is provided which can then be used to release and seat one or more spring-loaded patient needles into the skin surface, and establish a fluid communication path between the patient needles and the pressurized fluid reservoir contents thereby delivering an infusion into the skin.

An abrader device for delivering a substance into skin via an abrasion process includes a housing adapted to be pressed against the skin at a desired delivery site, an applicator head disposed in an upper opening of the housing and movable across a lower opening of the housing to abrade the delivery site in at least one furrow, and an abrader surface attached to the applicator head whereby the housing remains firm and stationary at the delivery site and structure of the housing and the applicator head controls parameters of the abrasion process. In particular, the amount of force or pressure applied to the abrader surface, the speed at which the abrader surface moves across the skin and the number of lateral passes of the abrader surface across the skin are controlled so that the abrader device provides a furrow with a length of substantially the same depth thereby providing reproducible results, even though different technicians are applying the abrader device against a patient's skin.

Microabrader with controlled abrasion features

Growing community of inventors

Raleigh, NC, United States of America

Alexander George Lastovich