University of Leeds

Alexander Fred Markham

David Mark Meredith

Stephen Evans

Adrian Whitehouse

Aida Meredith, Legal Representative

Sunjie Ye

Philip Alan Robinson

Kersten Hall

Patricia Louise Coletta

Stephen Derek Evans

The present application relates to a method for the production of a noble metal nanomaterial comprising: (A) adding an aqueous solution of a source of noble metal ions and a reducing agent to an aqueous solution of an organic compound to form a reaction mixture, wherein the organic compound is capable of undergoing 2D planar stacking in aqueous solution; and (B) separating the noble metal nanomaterial from the reaction mixture. The present application also relates to a noble metal nanomaterial manufactured according to said method.

Nanomaterials

A nucleic acid encoding a promoter and comprising a nucleic acid sequence of SEQ ID NO:1, fragments and/or variants thereof, for use in gene therapy derived from the(HVS) ORF73 (ECLFI) gene. The invention also includes a gene therapy system and an HVS vector system including the promoter.

[object Object]

A herpesvirus saimiri (HVS) vector which has inserted therein at least a part of a gene encoding an envelope protein of HIV for use in delivering said protein to a specific cell population such as T cell lymphocytes and/or macrophages. The invention also provides a vaccine comprising the recombinant vector.

HIV vaccine

The invention relates to manipulation of equine herpes virus for use in gene therapy and in particular to modifications of the virus so that it can carry heterologous material and furthermore, preferably, be replication deficient so that the virus cannot replicate in the target tissue.

EHV-1 vectors

The invention relates to herpesvirus saimiri viruses that are genetically modified by mutations and/or deleting specific essential and non-essential genes. The essential genes are required in replication of viral genes and are needed for viral proliferation. The non-essential genes can represent sites for the insertion of heterologous genetic material.

Growing community of inventors

Leeds, United Kingdom

Alexander Fred Markham