Johns Hopkins University

University of Utah Research Foundation

Cancer Institute

Zeneca Limited

Imperial Chemical Industries Limited

Other

Cancer Institute, Japanese Foundation for Cancer Research

The Univ. of Utah

Japanese Foundation for Cancer Research Cancer Institute

Zeneca Pharmaceuticals

Astrazeneca United Kingdom, Ltd.

Alexander Fred Markham

Rakesh Anand

Bert Vogelstein

Kenneth W Kinzler

Raymond L White

Hans Albertsen

Philip John Hedge

Geoff Joslyn

Mary Carlson

Joanna Groden

Andrew Thliveris

Yusuke Nakamura

Clive R Newton

Donald James Ogilvie

John Hamilton Riley

Rashida Anwar

John Craig Smith

Yusuke Nakumura

Yusuka Nakamura

Andrew Thilveris

David Mark Meredith

Paul Elvin

A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.

APC antibodies

APC Antibodies

The invention relates to manipulation of equine herpes virus for use in gene therapy and in particular to modifications of the virus so that it can carry heterologous material and furthermore, preferably, be replication deficient so that the virus cannot replicate in the target tissue.

EHV-1 vectors

Diagnosis for mutant APC by immunoassay

Detection of APC proteins

Yeast Artificial Chromosomes (YACS) containing DNA encoding the cystic fibrosis (CFTR) gene are described. The YACs allow detailed analysis of the coding and non-coding regions of the gene and the determination of cystic fibrosis alleles in sample DNA from an individual or individuals.

Yeast artificial chromosomes containing DNA encoding the cystic fibrosis

APC (adenomatous polyosis coli) protein

Methods are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. APC is a tumor suppressor.

Detection of inherited and somatic mutations of APC gene in colorectal

The present invention relates to a method for detecting the presence or absence of one or more variant nucleotide sequences. The method comprises (i) contacting a nucleic acid sample with a diagnostic primer which is substantially complementary to a diagnostic portion of a target base sequence, whereby extension of the diagnostic primer on a target template under appropriate conditions is only achieved where a terminal nucleotide of the diagnostic primer is complementary to either a suspected variant nucleotide or a corresponding normal nucleotide of the target base sequence, and (ii) detecting the presence or absence of an extension product. Kits for performing diagnostic tests are also disclosed.

Method of detecting nucleotide sequences

APC gene and nucleic acid probes derived therefrom

Growing community of inventors

Crewe, United Kingdom

Alexander Fred Markham