Monte Rosa Therapeutics Ag

Black Diamond Therapeutics, Inc.

Monte Rosa Therapeutics, Inc.

F. Hoffmann-la Roche Ag

Alexander Flohr

Roland Jakob-Roetne

Johannes Aebi

Jens-Uwe Peters

Guido Galley

Wolfgang Wostl

Eric Argirios Kitas

Bernhard Fasching

Thomas Ryckmans

Claus Riemer

Matthew C Lucas

Lucinda Steward

Luca Arista

Elizabeth Buck

Andreas Ritzén

Jean-Luc Moreau

Nicolas Zorn

Fernando Padilla

Freya Harvey

Laura Mcallister

Sonia Poli

Roger Norcross

Dela Golshayan

Lucienne Juillerat-Jeanneret

The present disclosure relates to compounds of Formula (I′): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparation these compounds, compositions comprising these compounds, and methods of using them in the prevention or treatment of abnormal cell growth in mammals, especially humans.

Alkynyl quinazoline compounds

Disclosed herein are compound or pharmaceutically acceptable salts or stereoisomers thereof of formula I: Xis linear or branched Calkyl, Ccycloalkyl, Caryl, 5-10 membered heteroaryl, 4-8 membered heterocycloalkyl, wherein Xis unsubstituted or substituted with one or more of halogen, linear or branched Calkyl, linear or branched Cheteroalkyl, CF, CHF, CMeF, —O—CHF, —O—(CH)—OMe, OCF, Calkylamino, —CN, —N(H)C(O)—Calkyl, —OC(O)—Calkyl, —OC(O)—Calkylamino, —C(O)O—Calkyl, —COOH, —CalkylC(O)OH, —CalkylC(O)O—Calkyl, NH, Calkoxy, Calkylhydroxy, —CHF, —N(H)C(O)—O—Calkyl, and C(OH)(CF); or Xtogether with the N atom of the carbamate forms a 4-8 membered heterocycloalkyl, which is unsubstituted or substituted with one or more of halogen, linear or branched —Calkyl, CF, CHF, CMeF, —O—(CH)—OMe, OCF, OCHF, Calkylamino, —CN, —N(H)C(O)—Calkyl, —OC(O)—Calkyl, —C(O)O—Calkyl, —COOH, —CalkylC(O)OH, —CalkylC(O)O—Calkyl, NH, Calkylhydroxy, and Calkoxy; Xis H, Ccycloalkyl, Caryl, 5-10 membered heteroaryl, 4-8 membered heterocycloalkyl, wherein Xis unsubstituted or substituted with one or more of linear or branched Calkyl, —Calkoxy, NH, NMe, halogen, CF, CHF, CMeF, —O—(CH)—OMe, OCF, OCHF, and Calkylhydroxy; Lis a covalent bond, linear or branched Calkyl; Lis a covalent bond, linear or branched Calkyl; and Lis a covalent bond, linear or branched Calkyl, —O—, or —Calkoxy, wherein linear or branched Calkyl is unsubstituted or substituted with one or more of halogen. Disclosed herein is also their use as modulators of cereblon, methods of preparation of these compounds, compositions comprising these compounds, and methods of using them in the treatment of abnormal cell growth in mammals, especially humans.

Isoindolinone compounds

Growing community of inventors

Basel, Switzerland

Alexander Flohr