Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Boehringer Ingelheim Pharma Kg

Alexander Dreyer

Klaus Rudolf

Stephan Georg Mueller

Henri Doods

Dirk Stenkamp

Philipp Lustenberger

Kirsten Arndt

Gerhard Schaenzle

Marco Santagostino

Eckhart Bauer

Fabio Paleari

Marcus Schindler

Kai Gerlach

Rudolf Hurnaus

Wolfgang Eberlein

Dirk Gottschling

Annekatrin Charlotte Heimann

Rudlof Klaus

The present invention relates to new CGRP-antagonists of general formula I wherein R, R, R, R, R, R, X, Y and Z are defined as mentioned hereinafter, the individual diastereomers, the individual enantiomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, medicaments containing these compounds, the use thereof and processes for the preparation thereof.

Substituted piperazines as CGRP antagonists

The present invention relates to the CGRP antagonists of general formula wherein A, X, D, E, G, M, Q and Rto Rare defined as in claimthe tautomers, the isomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.

Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions

CGRP antagonists of the formula of which the following are exemplary:

CGRP antagonists

The present invention relates to the CGRP antagonists of general formula wherein A, X, D, E, G, M, Q and Rto Rare defined as in claim,the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.

The present invention relates to the CGRP antagonists of general formula wherein A, X, D, E, G, M, Q and Rto Rare defined as in claim 1,

The present invention relates to CGRP antagonists of general formula wherein A, U, V, W, X and Rto Rare defined as in claimthe tautomers, diastereomers, enantiomers, hydrates, mixtures thereof and the salts thereof as well as the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them.

Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions

The present invention relates to substituted piperidines of general formula wherein R, Rto R, A, X, Z and n are defined as in claim 1, the tautomers, diastereomers, enantiomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.

Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof

The present invention relates to the CGRP antagonists of general formula wherein A, X, D, E, G, M, Q and Rto Rare defined as in claim,

Selected CGRP&#x2014;antagonists, process for preparing them and their use as pharmaceutical compositions

The present invention relates to substituted piperidines of general formulawherein R, Rto R, A, X, Z and n are defined as in claim 1, the tautomers, diastereomers, enantiomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.

The present invention relates to substituted piperidines of general formulawherein

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Gutenzell-Huerbel, Germany

Alexander Dreyer