Sensys Medical, Inc.

Other

Instrumentation Metrics, Inc.

Alexander D Lorenz

Timothy Lewis Ruchti

Thomas B Blank

Kevin H Hazen

Stephen L Monfre

Mutua Mattu

Marcy R Makarewicz

George M Acosta

Stephen F Malin

Suresh Thennadil

Tamara L Troy

Suresh N Thennadil

James Matthew Welch

Roxanne E Abul-Haj

James Ryan Henderson

Christopher C Briggs

Donovan D Berry

A modular water-resistant paneling system and method is configured for being retrofitted into walls of existing finished basements or buildings and/or used in new construction, using components fastenable onto wall studs supporting drywall. The components include dimensionally stable water-resistant panels, and finishing strips having a backing flange and an upper lip portion sized and shaped to receive upper edge portions of the panels therein. The backing flange is fastenable to the wall studs while maintaining the panels in spaced relation therefrom, to maintain interior facing surfaces of the panels and drywall flush with one another. The upper lip portion includes opposing flanges configured for superposed engagement with adjacent portions of the interior facing surfaces of the panels and drywall. Mounting clips are sized and shaped for receiving a stud therein, and have a support flange for supporting lower edge portions of the panels.

Flood resistant wall

Concrete slab

A walk-behind apparatus and method for cutting non-linear trenches in concrete includes a frame supported by fixed direction wheels at a front end on a fixed axis of rotation, and multi-directional wheels at a rear end to rotate on movable axes of rotation, to permit the frame to rotate about a vertical axis passing through the frame. A handle is engageable by a user walking behind the frame for pushing the apparatus forward and/or for steering. A cutting wheel has a diameter of 5-20 inches and a cutting portion having a width of 0.5-1.5 inches. The cutting rotates on an axis parallel to the fixed axis and which extends notionally through the fixed direction wheels. The cutting wheel is disposed within a protective shroud viewable by the user to permit the user to visually align and guide the cutting wheel along a non-linear path on the ground while steering.

Method and apparatus for cutting non-linear trenches in concrete

A portable apparatus and method for cutting linear trenches in a concrete ground surface includes two bars extending in parallel spaced relation along the concrete with an elongated track removably fastened and extending orthogonally thereto. A trolley supporting a motor-driven cutting wheel is movably engaged with the track. A depth adjuster alternately lowers and raises the cutting wheel to engage and disengage the concrete while the trolley follows contours of the concrete to cut a kerf of uniform depth. The track is selectively movable to spaced locations along the lengths of the two bars to cut a first plurality of parallel kerfs in a first direction. The apparatus is rotatable about a vertical axis to cut a second plurality of parallel kerfs oriented in a second direction at a predetermined angle, e.g., 90 degrees, to the first direction, to form a simulated tile pattern in the concrete.

Method and apparatus for cutting linear trenches in concrete

This invention provides a method and apparatus that corrects for tissue related interference calibration and/or measurement of biological parameters noninvasively. The invention concerns such terms as outlier identification, filtering, spectral correction, and baseline subtraction steps that, when used together, provides for noninvasive measurement of biological parameters, such as glucose concentration.

Method of processing noninvasive spectra

The invention comprises transformation of a section of a data block independently of the transformation of separate or overlapping data blocks to determine a property related to the original matrix, where each of the separate or overlapping data blocks are derived from an original data matrix. The transformation enhances parameters of a first data block over a given region of an axis of the data matrix, such as signal-to-noise, without affecting analysis of a second data block derived from the data matrix. This allows for enhancement of analysis of an analyte property, such as concentration, represented within the original data matrix. A separate decomposition and factor selection for each selected data matrix is performed with subsequent score matrix concatenization. The combined score matrix is used to generate a model that is subsequently used to estimate a property, such as concentration represented in the original data matrix.

Method and apparatus for enhanced estimation of an analyte property through multiple region transformation

An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.

Optical sampling interface system for in-vivo measurement of tissue

A method and apparatus are provided for noninvasive sampling. More particularly, the method and apparatus relate to control of motion of an optical sample probe interface relative to a tissue sample site. A dynamic probe interface, is used to collect spectra of a targeted sample, control positioning of the sample probe relative to the tissue sample in terms of at least one of x-, y-, and z-axes, and/or control of sample tissue displacement to minimize spectral variations resulting from the sampling process and increase analyte property estimation precision and accuracy.

Noninvasive analyzer sample probe interface method and apparatus

A method and apparatus for noninvasive glucose measurement measures glucose indirectly from the natural response of tissue to variations in analyte concentration. The indirect measurement method utilizes factors affected by or correlated with the concentration of glucose, such as refractive index, electrolyte distribution or tissue scattering. Measurement reliability is greatly improved by stabilizing optical properties of the tissue at the measurement site, thus blood perfusion rates at the sample site are regulated. Perfusion is monitored and stabilized by spectroscopically measuring a control parameter, such as skin temperature, that directly affects perfusion. The control parameter is maintained in a range about a set point, thus stabilizing perfusion. Skin temperature is controlled using a variety of means, including the use of active heating and cooling elements, passive devices, such as thermal wraps, and through the use of a heated coupling medium having favorable heat transfer properties.

Method and apparatus for control of skin perfusion for indirect glucose measurement

The invention comprises a method and apparatus for enhancing the analysis of noninvasive spectra, resulting in improved analytical performance. More particularly, the invention comprises a method and apparatus for processing noninvasive spectra with an analyte filter that preferably rejects variation likely to be detrimental to the measurement system, while passing signal that probabilistically is unique to the target analyte. Subsequently, the analyte filtered data are used to estimate an analyte property, such as a glucose concentration, in the presence of noise, interferences, state changes, and/or across analyzers.

Analyte filter method and apparatus

The invention relates to a noninvasive analyzer and a method of using information determined at least in part from in-vitro spectra of tissue phantoms or analyte solutions to aid in the development of a noninvasive glucose concentration analyzer and/or in the analysis of noninvasive spectra resulting in glucose concentration estimations in the body. The preferred apparatus is a spectrometer that includes a base module and a sample module that is semi-continuously in contact with a human subject and that collects spectral measurements which are used to determine a biological parameter in the sampled tissue, such as glucose concentration. Collection of in-vitro samples is, optionally, performed on a separate instrument from the production model allowing the measurement technology to be developed on a research grade instrument and used or transferred to a target product platform or production analyzer for noninvasive glucose concentration estimation.

Method of adapting in-vitro models to aid in noninvasive glucose determination

An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement. Separate components of system can be individually deployed.

Growing community of inventors

Chandler, AZ, United States of America

Alexander D Lorenz