Formulogics, Inc.

American Cyanamid Company

Imc-agrico Co.

Alexander D Lindsay

Barry A Omilinsky

Willis L Thornsberry, Jr

Allen R Sutton

Willis L Thornsberry

Improved solvent systems for the formulation of N-alkyl thiophosphoric triamide urease inhibitors. These formulations enable the preparation of stable concentrated solutions of N-alkyl thiophosphoric triamides for storage, transportation, and eventual impregnation onto solid urea containing fertilizers and incorporation into liquid urea containing fertilizer compositions. These formulations are comprised primarily of a solvent selected from the group consisting of glycols and glycol derivatives. Optionally, in addition to the glycol base solvent, the formulations can contain a co-solvent selected from the group consisting of liquid amides, 2-pyrrolidone and N-alkyl 2-pyrrolidones, and/or a nonionic surfactant selected from the group consisting of alkylaryl polyether alcohols. The presence of the co-solvent and/or surfactant has been found to impart desirable properties to the formulations under certain conditions. N-alkyl thiophosphoric triamides have been known for some time to be effective inhibitors of the activity of urease enzymes, however, commercial use has been inhibited by the lack of an acceptable carrier. They are often thermally and hydrolytically unstable and difficult to handle. The use of the solvent systems offers many advantages including: (1) improved stability of the active ingredient urease inhibitor; (2) excellent solubility characteristics; (3) extremely low flammability and toxicity of the solvents; (4) excellent cold temperature storage and handling characteristics with the addition of the liquid amide co-solvent; and (5) good adsorption characteristics onto solid urea containing fertilizers and excellent miscibility with liquid urea containing fertilizer formulations.

Formulation for fertilizer additive concentrate

The cleanliness of water-rinsed surfaces originally carrying hazardous compositions is determined by using a surface active agent as a marker in said material prior to placing the composition into contact with the surface.

Determination of contaminants

Environmentally-acceptable intimate mixtures of active ingredients and excipients which meet economic performance levels are prepared without use of harmful solvents by solubilizing and mixing the components in liquid carbon dioxide maintained under pressure and then slowly reducing the pressure to convert the carbon dioxide to the gaseous phase and venting the gaseous carbon dioxide.

Method of preparing mixtures of active ingredients and excipients using

There is provided a composition comprising (a) a major amount of a calcined granular carrier of montmorillonite type of clays and (b) a minor amount of a broad spectrum insecticide-nematocide, namely, 0,0-diethyl S-[(1,1-dimethylethyl)thio]phosphorodithiorate, wherein said composition is distinguished by decreased mammalian dermal toxicity in contrast to conventional solid compositions containing the above-identified insecticide-nematocide.

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East Brunswick, NJ, United States of America

Alexander D Lindsay