Bristol-myers Squibb Compnay

Alexander Bertok

Erik A Rubin

Peng Zhou

Victor W Rosso

Waldemar Ruediger

Harold Norris Weller, Iii

Joseph Nolfo

A Erik Rubin

Carl J Trpisovsky

Walter Ruediger

Edward Joseph Kuspiel

The base of the modular reactor includes a frame which defines an opening into which one of a plurality of interchangeable reaction vessel carrying inserts can be removeably received. Each insert has an array of recesses adapted to receive a different number of reaction vessels of different sizes. The recesses are positioned such that all arrays are suitable for use with a standard automated liquid handier. The frame has fluid flow channels for regulating the temperature of the lower portions of the vessels. A temperature control module can be received over the base to regulate the temperature of the upper portions of the vessels for reflux reactions. The corner radii of the insert and frame opening cooperate to permit the insert to be received in the frame in only one orientation. The walls of the insert are inclined to facilitate removal by a friction fit tool. Each vessel receiving recess has a self-centering conical or semi-circular shaped bottom to maximize heat transfer and distribute the load uniformly. The vessels seat as close to the bottom surface of the base as possible to facilitate use with an air driven magnetic stirrer. A thin, electrically heated plate may be received between the base and the stirrer.

Parallel chemistry reactor with interchangeable vessel carrying inserts

A bifurcated bracket carries two powder dispensing assemblies. Each assembly includes a powder reservoir and a rotatable screw received within a compliant silicone sleeve. The outer diameter of the screw is slightly larger than the inner diameter of the sleeve such that the screw blade maintains direct contact with the sleeve wall as the screw is rotated. The bracket is sequentially moved to align each assembly with containers in two arrays. Each array of containers is situated in a tray. The trays are manually positioned on independent scales which generate signals that are a function of the sensed weight of each array. To fill each container, the screw in the aligned assembly is rotated at a high rate for an initial period and then at a slower rate. The scales are operational only during the slower rate period. Assembly movement and screw rotation are computer controlled.

Automated apparatus for dispensing measured quantities of powder to containers in an array

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Edison, NJ, United States of America

Alexander Bertok