Rutgers, the State University of New Jersey

Alexander A Poulev

Ilya Raskin

David M Ribnicky

The present disclosure provides methods for obtaining gaultherin, a natural salicylate derivative, from plant tissue. The methods involve preventing the hydrolysis of the gaultherin in the plant tissue by disrupting the plant tissue under solvent conditions lacking a drying agent. The disclosure further provides various forms of plant-derived gaultherin, including alcoholic extracts, aqueous solutions and dried preparations, all suitable for use as a natural aspirin substitute. Moreover, the disclosure provides methods of using gaultherin-containing compositions to increase serum salicylic acid, to treat cancer cells, to treat cardiovascular (e.g., cardiopulmonary) conditions, to treat anti-inflammatory responses, and to inhibit cyclooxygenase.

Methods of administering gaultherin-containing compositions

The present invention provides methods for obtaining phenethyl isothiocyanate (PEITC), a natural glucosinylate derivative, from plant tissue. The methods involve selection of plant tissue naturally rich in PEITC, followed by aqueous extraction under conditions that promote optimal release of PEITC from the tissue. The invention further provides plant preparations containing significant quantities of PEITC and nutraceutical formulations comprising these preparations.

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Highland Park, NJ, United States of America

Alexander A Poulev