Ciba-geigy Corporation

Alex Sele

Alberto Rossi

Knut A Jaeggi

Georges Haas

Gerhard Baschang

Pier G Ferrini

Jaroslav Stanek

Jean M Tronchet

Bruno Baehler

3,4-Dihydro-2H-1,2-benzothiazine 1,1-dioxides of the formula ##STR1## wherein Ph represents a substituted or unsubstituted 1,2-phenylene radical, R represents a substituted or unsubstituted benzopyrone radical, and R.sub.1 represents hydrogen or a substituted or unsubstituted hydrocarbon radical of aliphatic character, and their salts, possess antiinflammatory properties and are useful as medicaments.

N,N-Di and N,N,N-tri(hydroxy-lower alkyl) ammonium salts of substituted

New 4,7-phenanthroline derivatives of the formula (I) ##STR1## in which Ch represents an optionally substituted 5,6-quinolinylene radical of which the 6-position is joined to the --N(R.sub.E)-- group, and

Novel 4,7-phenanthroline derivatives and pharmaceutical compositions

The present invention relates to novel benzopyrane derivatives, especially 3-oxaloamino-4-oxo-4H-1-benzopyrane derivatives of the formula I ##STR1## in which Ph is substituted or unsubstituted 1,2-phenylene, R is free, esterified or amidated carboxyl and R.sub.1 is hydrogen or a substituted or substituted hydrocarbon radical, in the free from or in the form of a salt, exhibit antiallergic activities and are accordingly useful as active ingredients of antiallergic pharmaceutical preparations.

Process for the preparation of novel benzopyrane derivatives

The present invention relates to novel benzopyrane derivatives, especially 3-oxaloamino-4-oxo-4H-1-benzopyrane derivatives of the formula I ##STR1## in which Ph is substituted or unsubstituted 1,2-phenylene, R is free, esterified or amidated carboxyl and R.sub.1 is hydrogen or a substituted or substituted hydrocarbon radical, in the free form or in the form of a salt, exhibit antiallergic activities and are accordingly useful as active ingredients of antiallergic pharmaceutical preparations.

Azathianaphthalenes

The invention relates to processes for the preparation of novel aryl-hexafuranosides of the formula ##STR1## in which R.sub.1 is lower alkyl or cycloalkyl and R.sub.2 is hydrogen, lower alkyl or acyl, or R.sub.1 and R.sub.2 together are alkylidene or cycloalkylidene, R.sub.3 is hydrogen, lower alkyl, lower alkenyl or aryl-lower alkyl, R.sub.5a and R.sub.6a independently of one another are hydrogen or lower alkyl, R.sub.5b and R.sub.6b independently of one another are hydrogen, hydroxyl, lower alkoxy or amino, or R.sub.5b and R.sub.6b together are a C--C bond, epoxy or lower alkylidene, and R.sub.6c is aryl, by methods known per se. These novel compounds have an anti-inflammatory and/or antinociceptive action.

Novel aryl-hexafuranosides and processes for their preparation

The invention relates to novel 1,6-anhydro-.beta.-D-hexopyranose derivatives of the formula I ##STR1## in which R.sub.2 is hydrogen, methyl or aromatic acyl, R.sub.3 and R.sub.4 are alkyl, alkenyl or aralkyl and one of the radicals R.sub.3 and R.sub.4 is also an aroyl radical and R.sub.4 can also be hydrogen, with the proviso that the radicals R.sub.3 and R.sub.4 together contain at least 3 carbon atoms and, if R.sub.4 is the benzyl radical, the radical R.sub.3 contains at least 2 carbon atoms, and, if one of the radicals R.sub.3 and R.sub.4 is an aroyl radical, R.sub.2 is hydrogen. These compounds especially the 1,6-anhydro-3,4-di-O-benzyl-.beta.-D-glucopyranose or the 1,6-anhydro-.beta.-D-glucopyranose, can be used as fibrinolytic agents and thrombolytic agents.

Anhydro-sugars

The invention relates to furanose-O-pyridylcarboxylic acid esters, such as the ethyl-2-O-methyl-3,5,6-tri-O-nicotinoyl-D-glucofuranoside, which have anti-inflammatory activity and are fibrinolysis activators. They can be used for the treatment of rheumatic and neuralgic complaints, and especially for the topical percutaneous treatment of localized inflammatory processes.

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Muttenz, Switzerland

Alex Sele