Cytokinetics, Inc.

Amgen Inc.

Alex R Muci

Bradley Paul Morgan

Pu-Ping Lu

David John Morgans, Jr

Erica Anne Kraynack

Todd Tochimoto

Gustave Bergnes

Xiangping Qian

Scott E Collibee

Zhe Yang

Chihyuan Chuang

Jeffrey Warrington

Luke W Ashcraft

Antonio Romero

Jeff Gardina

Jeffrey T Finer

Alan James Russell

Fady Malik

Alan Martin Allgeier

Kathleen Ann Elias

Whitney Walter Smith

Sheng Cui

Karthik Nagapudi

Henry Morrison

Steven Mennen

Charles Bernard

Neil Fred Langille

Karl Bennett Hansen

Adam Lewis Tomasi

Shawn D Walker

Jacqueline C S Woo

David J Morgans

Brian M Stoltz

Jianchao Wang

Marc Andrew Garard

David Morgans

Jacqueline Woo

William F Browne, Iv

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Compounds, compositions and methods

Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.

Salt of omecamtiv mecarbil and process for preparing salt

Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, R, R, X and mare as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Amino-pyrimidine skeletal muscle modulators

Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, R, R, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Provided are methods of preparing compounds of Formula 201: 

Methods for preparing substituted imidazo[4,5-b]pyrazines

Substituted pyridazines as skeletal muscle modulators

Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R, R, R, R, R, R, R, X, Z, Z, Z, Zand m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use

Growing community of inventors

South San Francisco, CA, United States of America

Alex R Muci