The Cleveland Clinic Foundation

Alex Massiello

David J Horvath

Leonard A R Golding

Barry D Kuban

Shubhayu Basu

Eugene J Jung

Kiyotaka Fukamachi

Ray Dessoffy

Mariko Kobayashi

Leonard Golding

Leonard AR Golding

A method is provided of controlling a pump including a electrical motor coupled to a rotor which carries first and second impellers at opposite ends thereof. The method includes: (a) driving the rotor using the motor, so as to circulate fluid from the first impeller through a first fluid circuit, the second impeller, a second fluid circuit, and back to the first impeller; (b) determining a resistance of the first fluid circuit, based on a first motor parameter which is a function of electrical power delivered to the motor; (c) determining a flow rate through the first fluid circuit based on a second motor parameter which is a function of electrical power delivered to the motor; and (d) varying at least one operational parameter of the pump so as to maintain a predetermined relationship between the flow rate and the resistance of the first fluid circuit.

Method for physiologic control of a continuous flow total artificial heart

A pump includes a housing, a stator supported in the housing, and a rotor assembly including a rotor supported in the housing for rotation relative to the stator about an axis. The stator includes a stator core, a first lamination wound around an axial portion of the stator core, and a second lamination wound around a second axial portion of the stator core. The first and second laminations are spaced from each other along the length of the stator core. The rotor includes a rotor core, a first magnet assembly that extends around an axial portion of the rotor core, and a second magnet assembly that extends around a second axial portion of the rotor core. The first and second magnet assemblies are spaced from each other along the length of the rotor.

Two-stage rotodynamic blood pump

Treatment of heart failure in a patient by electrically modulating both the sympathetic and parasympathetic autonomic cardiac nerve fibers that innervate the patient's heart at an extravascular site in the pericardial space of the heart. The extravascular site is any suitable single location inside the chest cavity that carries both sympathetic and parasympathetic cardiac nerves such as the cardiac plexus or the pericardial transverse sinus or any two separate extravascular sites with one site carrying predominantly sympathetic cardiac nerves and the other site carrying predominantly parasympathetic cardiac nerves for electrically modulating the balance of autonomic cardiac nerve control. Physiologic inputs from a neuromodulation system's own sensors or from separate implanted or external cardiovascular hemodynamic sensor systems can be used for closed loop control over the balance of sympathetic and parasympathetic cardiac autonomic effects on the patient's cardiac function in real time response to chronic and transient physiologic needs.

Extravascular neuromodulation to treat heart failure

A method is provided of controlling a pump including a electrical motor coupled to a rotor which carries first and second impellers at opposite ends thereof. The method includes: (a) driving the rotor using the motor, so as to circulate fluid from the first impeller through a first fluid circuit, the second impeller, a second fluid circuit, and back to the first impeller; (b) determining a resistance of the first fluid circuit, based on a first motor parameter; (c) determining a flow rate through the first fluid circuit based on a second motor parameter; and (d) varying at least one operational parameter of the pump so as to maintain a predetermined relationship between the flow rate and the resistance of the first fluid circuit.

A pump () includes a housing, a stator () supported in the housing, and a rotor assembly (). The rotor assembly () includes a rotor () supported in the housing for rotation relative to the stator () about an axis (). The rotor assembly () also includes a first impeller () operatively coupled to a first axial end of the rotor () for rotation with the rotor about the axis (). The rotor assembly further includes a second impeller () operatively coupled to a second axial end of the rotor (), opposite the first axial end, for rotation with the rotor about the axis (). The rotor assembly () is movable along the axis () relative to the housing to adjust hydraulic performance characteristics of the pump ().

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Chesterland, OH, United States of America

Alex Massiello