Profusa, Inc.

Alex Kutyavin

Soya Gamsey

Jacob William Clary

Sulolit Pradhan

Viachaslau Bernat

Glucose-sensing luminescent dyes of formula (IV-I), polymers, and sensors are provided. Additionally, systems including the sensors and methods of using these sensors and systems are provided.

Near-IR glucose sensors

The present invention is directed, in certain embodiments, to polymerizable near-IR dyes and polymers comprising said dyes as monomeric residues. In other embodiments, the present invention also relates to methods for the preparation of polymerizable near-IR dyes, and to the use of polymerizable near-IR dyes in the preparation of fluorescent polymers.

Polymerizable near-IR dyes

The present disclosure provides polymerizable luminescent dyes useful for incorporation into polymers. The dyes and the polymers can be used in sensing and imaging applications, for example, to provide accurate and optionally long term measurements of glucose in vivo. The present disclosure also provides sensors including the polymers described herein. The sensors can be implanted into a tissue of a subject and used for long-term or short-term continuous and semi-continuous collection of data of various biochemical analytes, optionally without the use of implantable hardware of any type and/or enzymatic and electrochemical detection methods.

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Lake Stevens, WA, United States of America

Alex Kutyavin