Ge Healthcare Limited

Amersham Plc

Nycomed Amersham Plc

Alex Gibson

Roger Olsson

Anthony Eamon Storey

Marivi Mendizabal

Ian Andrew Wilson

Peter Knox

Susan Champion

Benedicte Guilbert

Alan Michael Forster

Timothy Charles Richardson

James Nairne

Veronique Morisson Iveson

Jorgen Eskildsen

Ethan Burstein

Edward Robins

Joel Castillo

Anne Eeg Knapp

Synthetic analogues of lysine and glutamine are provided which function as substrates for the fibrin-stabilising enzyme Factor XIIIa even when labelled with a detectable moiety. The use of suitable protecting groups provides compounds which possess reduced susceptibility to in vivo metabolism especially by peptidases, and are hence useful agents for the diagnosis of thrombosis, embolism, atherosclerosis, inflammation or cancer.

Labelled glutamine and lysine analogues

A complex of a radiometal or paramagnetic metal ion with a metal chelating agent such as a diaminedioxime has attached thereto a substituent of formula (Y)-A-NHR)can function as a substrate for the fibrin-stabilizing Factor XIIIa. The complex is useful for the diagnosis or therapy of thrombosis, embolism, atherosclerosis, inflammation or cancer.

Labelled factor XIIIa substrates

A complex of a radiometal or paramagnetic metal ion with a metal chelating agent such as a diaminedioxime has attached thereto a substituent of formula &mdash;(Y) &mdash;A&mdash;NHR, can function as a substrate for the fibrin-stabilizing Factor XIIIa. The complex is useful for the diagnosis or therapy of thrombosis, embolism, atherosclerosis, inflammation or cancer.

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Little Chalfont, United Kingdom

Alex Gibson