B. Braun Avitum Ag

Alex Castellarnau

Christof Strohhoefer

Silvie Krause

Stefan Moll

Joern Ahrens

Jörn Ahrens

Joern Meibaum

Soeren Weyer

Aleksandr Frorip

Christoph Nacke

Jörn Meibaum

Jürgen Wagner

Control methods of a dialysis machine for allowing the dialysate-side detection of a recirculation in an arteriovenous shunt of a patient during ongoing hemodialysis are described. A sensor is arranged downstream of a dialyzer and detects a change of a physicochemical parameter Pof outflowing dialysis fluid. Control elements are provided to guide the dialysis fluid in a selected manner through the dialyzer or pass it by. Recirculation may be determined by passing the dialysis fluid by the dialyzer so that the dialysis fluid is guided unchanged along the sensor for calibration, switching the control elements after optional sensor calibration such that the dialysis fluid flows through the dialyzer, and adjusting a desired first blood flow value BFin the blood-side extracorporeal circulatory branch so that between an inlet of the extracorporeal circulatory branch and an outlet a recirculation R and, a first clearance Kare adjusted and the parameter detected by the sensor adopts a corresponding value P, changing the first blood flow value BFto a second blood flow value BF, wherein a second clearance Kis adjusted, and accordingly at the sensor a new parameter value Pis provided and detected, and determining the recirculation R by the course of change from the parameter value Pto the parameter value P.

Method of detecting recirculation in an arteriovenous shunt during ongoing hemodialysis and dialysis system

The invention describes an apparatus for extracorporeal blood treatment with a dialyzer which is separated by a semipermeable membrane in to a first and second chamber (), wherein the first chamber () is arrange in a dialysate pathway and the second chamber () is connectable to the blood circulation of a patient by means of a blood supply conduit () and a blood return conduit (), an inlet () for fresh dialysate, an outlet () for spent dialysate, a measuring device () arranged in the outlet (), wherein said measuring device () has at least one radiation source consisting of several light sources () for electromagnetic radiation. The invention is characterized in that the measuring device () is designed to generate substantially monochromatic electromagnetic radiation of different wavelengths, and to lead only one of these wavelength (at the same time) though the outlet () for spent dialysate, wherein at least one detector system () is provided for detection of the intensity or the absorption of the substantially monochromatic electromagnetic radiation passing through the outlet () for spent dialysate.

Apparatus for extracorporeal blood treatment

A method for determining online adequacy parameters for any hemodialysis, hemofiltration and hemodiafiltration treatment modality is provided. Blood equilibrated dialysate samples at the begin and/or at the end of the treatment; and a continuous measurements of waste compounds in the effluent dialysate by means of spectroscopic techniques, are required. With the data coming from the measurements and a simple mathematic approach Kt/V and reduction ratios for different compounds, which are important from the medical point of view, are obtained.

Method for determining the reduction ratio or the Kt/V value of a kidney substitution treatment and apparatus for the realisation of the method

A method for determining or predicting the adequacy parameters that will be achieved at the end of a kidney substitution treatment during said kidney substitution treatment wherein the kidney substitution treatment is provided by a machine, which has an extracorporeal blood system pumping the patient blood through the blood chamber of a dialyzer, wherein the dialyzing fluid collects the waste products from the patient after flowing through the dialyzing fluid chamber of the dialyzer and wherein a device able to measure a adequacy parameter is coupled with the kidney substitution treatment machine and wherein the slope of a preferable linear guideline for the adequacy parameter is compared to the slope of the delivered adequacy parameter and if the slope of both are equal a linearization is performed to determine or predict the adequacy parameter at the end of the kidney substitution treatment.

Method and device to early predict the Kt/V parameter in kidney substitution treatments

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Melsungen, Germany

Alex Castellarnau