Menarini Silicon Biosystems S.p.a.

Silicon Biosystems S.p.a.

Alex Calanca

Gianni Medoro

Nicolò Manaresi

Gerardo Perozziello

Giuseppe Giorgini

Giuseppina Simone

Nicolo' Manaresi

Giuseppe Sardella

Fabrizio Alberti

Method and apparatus for the reduction of the volume of a sample; the method comprises an acceleration step, during which a container containing the sample is accelerated so that a part of a liquid component of the sample flows out of an opening of one end of the container; according to some embodiments, the container is made to rotate around a rotation axis passing through the container; the container is orientated radially relative to the rotation axis with its opening facing outwards.

Method and apparatus for the reduction of the volume of a sample

Method and device () for performing the optical analysis of particles () contained in suspension in a fluid () arranged inside a microfluidic device () which maintains it at a temperature significantly lower than the ambient temperature; the formation of humidity on the outer surface () of the cover of the microfluidic device is avoided by applying a thermal flow (P) which determines an increase in the temperature of the outer surface () of the cover to above the condensation temperature (Td), or reduction in the ambient temperature (and/or humidity) in the vicinity of the cover (), so as to bring the condensation temperature (Td) (dew point) to below the temperature of the surface () of the cover determined by the internal operating temperature.

Method and device for optical analysis of particles at low temperatures

A microfluidic device for the isolation of particles of at least one specific type of a sample is described. The microfluidic device comprises: a first inlet adapted to receive a sample comprising the particles of the specific type, at least part of a separation group comprising a separation unit, which comprises a main chamber and a recovery chamber and being adapted to receive the sample and to transfer at least part of the particles of the specific type from the main chamber to the recovery chamber in a selective manner with respect to further particles of the sample, a first outlet which is designed to allow the particles of the specific type to be collected outside of the device and a second outlet adapted to allow at least a portion of the sample to flow out of the main chamber and out of the microfluidic device.

Microfluidic device, microfluidic system and method for the isolation of particles

A microfluidic system and method for the recovery of particles; the system comprises at least one standing chamber, at least one outlet, at least one inlet and a moving assembly, which is adapted to move the particles; a fluid is fed from the inlet to the outlet so as to generate a substantially continuous flow of the fluid; a given particle of a group of particles arranged in the collecting chamber is moved selectively with respect to the other particles of the assembly to a release area, in which a dragging force created by the fluid flow is such as to move the particle towards the outlet.

Microfluidic system and method for the recovery of particles

A microfluidic system for the isolation of particles of at least one given type belonging to a sample and comprising a separation unit, which is designed to transfer the particles of given type from a main chamber to a recovery chamber in a substantially selective manner with respect to further particles of the sample; at least one first reservoir, which is designed to contain a liquid and is fluidically connected to the separation unit; and a regulating assembly, which comprises at least a first regulating device having a first heat transfer element arranged at the first reservoir to adjust the temperature of the first reservoir, in particular to absorb heat from the reservoir.

Microfluidic system

Method for the treatment of a biological sample comprising at least one cell and a liquid component; according to the method, a force is applied to the sample inserted in an inner chamber of a hollow device towards a filter which has pores with diameters from 2 nm to 1 &#x3bc;m, so that at least part of the liquid component passes through the filter and the cell remains in the inner chamber, thus obtaining a concentrated sample; the filter has a surface facing the inner chamber of less than 12.6 mm.

Devices, apparatus, kit and method for treating a biological sample

A micro-fluidic system comprising a micro-fluidic channel, which has a wall provided with a hole; a closing element, which is partially housed within the hole and has a membrane portion adapted to deform and a side portion sealingly connected with the above mentioned wall; and a partition arranged within the micro-fluidic channel between a first and a second segment; the closing element is deformable between a locked configuration in contact with the partition and an open configuration spaced from the partition; the closing element may be deformed by suction or by a rod or a piston.

Micro-fluidic system

A sorting chamber () for sorting first particles () from second particles () comprising: an internal chamber (), which is delimited by a base wall (), a top wall (), and a spacer (), set between the base wall () and the top wall (); an internal chamber (), which is at least partially-delimited by the base wall () and top wall (); two passages (), which set in communication the internal chamber () with the external environment; and a plurality of cavities (), which are designed to house the first particles (), are made in the base wall () and have openings () towards the internal chamber () with widths of from 4 to 6 &#x3bc;m.

Sorting chamber for microscale particles

A microfluidic system () for the isolation of cells (C) of at least one given type from a sample; the system () comprises a separation unit (), for transferring at least part of the cells (C) of the given type from a main chamber () to a recovery chamber () in a substantially selective way with respect to further cells (C) of the sample; two valves () are set upstream and downstream of the main chamber (); two valves () are set upstream and downstream of the recovery chamber (); a control assembly () is designed to govern the aforementioned valves (); the system () proposed enables isolation of the cells with a high degree of reproducibility and precision.

Microfluidic device for isolation of cells

A micro-fluidic system comprising a micro-fluidic channel, which has a wall provided with a hole, within which a closing portion of a closing element extends; when the closing portion is arranged within the micro-fluidic channel, the passage of the liquid along the channel is interrupted; by deforming the closing element by suction the closing portion may be lifted and therefore allow the passage of liquid along the micro-fluidic channel.

A micro-fluidic system comprising a micro-fluidic channel, which has a wall provided with a hole; and a closing element, which is adapted to cooperate with a partition arranged within the micro-fluidic channel in the area of the hole to isolate or connect two segments of the channel; the closing element is made of a photoresist material, in particular a material obtained by the polymerisation of a photopolymerable material.

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Mirandola, Italy

Alex Calanca